799274-08-1

• 

• Basic information

  1. Product Name: 6-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
  2. Synonyms: 6-FLUORO-1,2,3,4-TETRAHYDROISOQUINOLINE HCL;6-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE;6-Fluoro-1,2,3,4-tetrahydro-isoquiniline hydrochloride;Isoquinoline, 6-fluoro-1,2,3,4-tetrahydro-, hydrochloride (1:1);6-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride≥ 95% (NMR);Isoquinoline, 6-fluoro-1,2,3,4-tetrahydro-, hydrochloride
  3. CAS NO:799274-08-1
  4. Molecular Formula: C₉H₁₀FN*ClH
  5. Molecular Weight: 187.64
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 799274-08-1.mol
  9. Article Data: 0

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: N/A
  3. Flash Point: N/A
  4. Appearance: /
  5. Density: N/A
  6. Refractive Index: N/A
  7. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
  8. Solubility: N/A
  9. CAS DataBase Reference: 6-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE(CAS DataBase Reference)
  10. NIST Chemistry Reference: 6-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE(799274-08-1)
  11. EPA Substance Registry System: 6-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE(799274-08-1)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 799274-08-1(Hazardous Substances Data)

• Suppliers
• Usage
• SDS
• Synthetic route
• Upstream product
• Downstream Products

799274-08-1 Suppliers

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• 6-Fluoro-1,2,3,4-tetrahydro-isoquinoline hydrochloride

  Cas No: 799274-08-1

• USD $ 3.0-3.0 / Kilogram

• 1 Kilogram

• 1-100 Metric Ton/Month

• Dayang Chem (Hangzhou) Co.,Ltd.
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• High quality 6-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride supplier in China

  Cas No: 799274-08-1

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• 1 Metric Ton

• 30 Metric Ton/Month

• Simagchem Corporation
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• 6-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE

  Cas No: 799274-08-1

• USD $ 1000.0-1300.0 / Gram

• 1 Gram

• 1 Kilogram/Month

• Hebei Nengqian Chemical Import and Export Co., LTD
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• Isoquinoline, 6-fluoro-1,2,3,4-tetrahydro-, hydrochloride (1:1) 799274-08-1

  Cas No: 799274-08-1

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• Shanghai Upbio Tech Co.,Ltd
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• 6-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE CAS:799274-08-1

  Cas No: 799274-08-1

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• Qingdao Beluga Import and Export Co., LTD
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• Isoquinoline, 6-fluoro-1,2,3,4-tetrahydro-, hydrochloride (1:1)

  Cas No: 799274-08-1

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• 1 Kilogram

• 1 Metric Ton/Day

• Shandong Hanjiang Chemical Co., Ltd.
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• Isoquinoline, 6-fluoro-1,2,3,4-tetrahydro-, hydrochloride (1:1)

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• Henan Wentao Chemical Product Co., Ltd.
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• 6-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride

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• Xiamen Hisunny Chemical Co.,Ltd
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• Isoquinoline, 6-fluoro-1,2,3,4-tetrahydro-, hydrochloride (1:1)

  Cas No: 799274-08-1

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• Hangzhou J&H Chemical Co., Ltd.
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• High quality 6-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride

  Cas No: 799274-08-1

• USD $ 100.0-100.0 / Gram

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• Zibo Hangyu Biotechnology Development Co., Ltd
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799274-08-1 Usage

Chemical Properties

Off white to yellow crystalline powder

Check Digit Verification of cas no

The CAS Registry Mumber 799274-08-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,9,9,2,7 and 4 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 799274-08:
(8*7)+(7*9)+(6*9)+(5*2)+(4*7)+(3*4)+(2*0)+(1*8)=231
231 % 10 = 1
So 799274-08-1 is a valid CAS Registry Number.

InChI:InChI=1/C9H10FN.ClH/c10-9-2-1-8-6-11-4-3-7(8)5-9;/h1-2,5,11H,3-4,6H2;1H

799274-08-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name	6-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

1.2 Other means of identification

Product number	-
Other names	6-fluoro-1,2,3,4-tetrahydroisoquinoline,hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:799274-08-1 SDS

799274-08-1Synthetic route

799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

79099-07-3

N-tert-butyloxycarbonylpiperidin-4-one

1018826-70-4

tert-butyl 4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: 6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride; N-tert-butyloxycarbonylpiperidin-4-one With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1h; Molecular sieve; Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; for 18h;	94%

799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

2369-11-1

5-fluoro-2-nitroaniline

5-(7-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2-nitroaniline

Conditions

Conditions	Yield
With iodine; triethylamine In dimethyl sulfoxide for 1.5h; Reflux; Inert atmosphere;	84%

1009344-67-5

N-(4-bromo-2,6-dimethylphenyl)-3,3-dimethylbutanamide

799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

1009344-33-5

N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide

Conditions

Conditions	Yield
With potassium tert-butylate; bis(dibenzylideneacetone)-palladium(0); DavePhos In toluene at 80℃;	83%
With potassium tert-butylate; bis(dibenzylideneacetone)-palladium(0); DavePhos In 2-methyltetrahydrofuran at 77℃; for 13h; Inert atmosphere;

211693-73-1

2-amino-3,4-difluoronitro-benzene

799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

2-fluoro-3-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-6-nitroaniline

Conditions

Conditions	Yield
With iodine; triethylamine In dimethyl sulfoxide for 3h; Reflux; Inert atmosphere;	74%

799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

2369-11-1

5-fluoro-2-nitroaniline

5-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2-nitroaniline

Conditions

Conditions	Yield
With iodine; triethylamine In dimethyl sulfoxide for 1.5h; Reflux; Inert atmosphere;	72%

799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

1323407-86-8

3-[4-[[4-(bromomethyl)phenyl]methoxy]-1-oxo-isoindolin-2-yl]piperidine-2,6-dione

1323403-99-1

3-{4-[4-(6-Fluoro-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-benzyloxy]-1-oxo-1,3-dihydro-isoindol-2-yl}-piperidine-2,6-dione

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	69%

799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

6-methyl-4-(methylthio)-1-{[5-(trifluoromethyl)thiophen-2-yl]methyl}-1,3,5-triazin-2(1H )-one

4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-6-methyl-1-{[5-(trifluoromethyl)thiophen-2-yl]methyl}-1,3,5-triazin-2(1H)-one

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane for 14h; Reflux;	26%
With triethylamine In 1,4-dioxane for 14h; Reflux;	26%

1009344-69-7

N-(4-Bromo-2-chloro-6-trifluoromethyl-phenyl)-3-cyclopentyl-propionamide

799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

1009344-27-7

N-[2-Chloro-4-(6-fluoro-3,4-dihydro-1H-isoquinolin-2-yl)-6-trifluoromethyl-phenyl]-3-cyclopentyl-propionamide

Conditions

Conditions	Yield
With potassium tert-butylate; bis(dibenzylideneacetone)-palladium(0); DavePhos In toluene at 90℃;

1009344-73-3

N-(4-Bromo-2-chloro-6-methylphenyl)-3,3-dimethyl butanamide

799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

1009344-39-1

N-[2-chloro-4-(6-fluoro-3,4-dihydro-1H-isoquinolin-2-yl)-6-methylphenyl]-3,3-dimethylbutanamide

Conditions

Conditions	Yield
With potassium tert-butylate; bis(dibenzylideneacetone)-palladium(0); DavePhos In toluene at 90℃;

799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

24424-99-5

di-tert-butyl dicarbonate

tert-butyl 6-fluoro-3,4-dihydroisoquinoline-2(1H)-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran; water at 20℃; for 18h;

799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

24424-99-5

di-tert-butyl dicarbonate

tert-butyl 8-fluoro-1,2-dihydro-3H-benzo[d]azepine-3-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium carbonate / water; tetrahydrofuran / 18 h / 20 °C 2: 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate / dichloromethane; diethyl ether / 1 h / 80 °C / Schlenk technique; Inert atmosphere View Scheme

211693-73-1

2-amino-3,4-difluoronitro-benzene

799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

ethyl (2-amino-3-fluoro-4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)phenyl)carbamate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: triethylamine; iodine / dimethyl sulfoxide / 3 h / Reflux; Inert atmosphere 2.1: zinc; ammonium chloride / methanol; tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere 2.2: 18 h / 10 - 20 °C / Inert atmosphere View Scheme

799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

2369-11-1

5-fluoro-2-nitroaniline

ethyl (2-amino-4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)phenyl)carbamate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: triethylamine; iodine / dimethyl sulfoxide / 1.5 h / Reflux; Inert atmosphere 2.1: zinc; ammonium chloride / methanol; water; 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere 2.2: 18 h / 20 °C / Inert atmosphere; Cooling with ice View Scheme

799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

2369-11-1

5-fluoro-2-nitroaniline

ethyl (2-amino-4-(7-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)phenyl)carbamate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: triethylamine; iodine / dimethyl sulfoxide / 1.5 h / Reflux; Inert atmosphere 2.1: zinc; ammonium chloride / methanol; tetrahydrofuran; water / 4 h / 20 °C / Inert atmosphere 2.2: 12 h / 20 °C / Inert atmosphere; Cooling with ice View Scheme

799274-08-1Upstream product

799274-08-1Downstream Products

• 224161-38-0 6-fluoro-3,4-dihydroisoquinoline 
• 1009344-39-1 N-[2-chloro-4-(6-fluoro-3,4-dihydro-1H-isoquinolin-2-yl)-6-methylphenyl]-3,3-dimethylbutanamide 
• 1009344-27-7 N-[2-Chloro-4-(6-fluoro-3,4-dihydro-1H-isoquinolin-2-yl)-6-trifluoromethyl-phenyl]-3-cyclopentyl-propionamide 
• 1009344-33-5 N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide 

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