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6-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride
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Name

6-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

 EINECS N/A
CAS No. 799274-08-1 Density N/A
PSA 12.03000 LogP 2.60220
Solubility N/A Melting Point N/A
Formula C9H10FN.HCl Boiling Point N/A
Molecular Weight 187.644 Flash Point N/A
Transport Information N/A Appearance N/A
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 799274-08-1 (6-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE) Hazard Symbols N/A
Synonyms

Isoquinoline,6-fluoro-1,2,3,4-tetrahydro-, hydrochloride (9CI);Isoquinoline, 6-fluoro-1,2,3,4-tetrahydro-, hydrochloride;

 

6-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride Synthetic route

799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

79099-07-3

N-tert-butyloxycarbonylpiperidin-4-one

1018826-70-4

tert-butyl 4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: 6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride; N-tert-butyloxycarbonylpiperidin-4-one With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1h; Molecular sieve;
Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; for 18h;		94%
799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

2369-11-1

5-fluoro-2-nitroaniline

5-(7-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2-nitroaniline

Conditions
ConditionsYield
With iodine; triethylamine In dimethyl sulfoxide for 1.5h; Reflux; Inert atmosphere;84%
1009344-67-5

N-(4-bromo-2,6-dimethylphenyl)-3,3-dimethylbutanamide

799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

1009344-33-5

N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide

Conditions
ConditionsYield
With potassium tert-butylate; bis(dibenzylideneacetone)-palladium(0); DavePhos In toluene at 80℃;83%
With potassium tert-butylate; bis(dibenzylideneacetone)-palladium(0); DavePhos In 2-methyltetrahydrofuran at 77℃; for 13h; Inert atmosphere;
211693-73-1

2-amino-3,4-difluoronitro-benzene

799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

2-fluoro-3-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-6-nitroaniline

Conditions
ConditionsYield
With iodine; triethylamine In dimethyl sulfoxide for 3h; Reflux; Inert atmosphere;74%
799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

2369-11-1

5-fluoro-2-nitroaniline

5-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2-nitroaniline

Conditions
ConditionsYield
With iodine; triethylamine In dimethyl sulfoxide for 1.5h; Reflux; Inert atmosphere;72%
799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

1323407-86-8

3-[4-[[4-(bromomethyl)phenyl]methoxy]-1-oxo-isoindolin-2-yl]piperidine-2,6-dione

1323403-99-1

3-{4-[4-(6-Fluoro-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-benzyloxy]-1-oxo-1,3-dihydro-isoindol-2-yl}-piperidine-2,6-dione

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;69%
799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

6-methyl-4-(methylthio)-1-{[5-(trifluoromethyl)thiophen-2-yl]methyl}-1,3,5-triazin-2(1H )-one

4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-6-methyl-1-{[5-(trifluoromethyl)thiophen-2-yl]methyl}-1,3,5-triazin-2(1H)-one

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane for 14h; Reflux;26%
With triethylamine In 1,4-dioxane for 14h; Reflux;26%
1009344-69-7

N-(4-Bromo-2-chloro-6-trifluoromethyl-phenyl)-3-cyclopentyl-propionamide

799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

1009344-27-7

N-[2-Chloro-4-(6-fluoro-3,4-dihydro-1H-isoquinolin-2-yl)-6-trifluoromethyl-phenyl]-3-cyclopentyl-propionamide

Conditions
ConditionsYield
With potassium tert-butylate; bis(dibenzylideneacetone)-palladium(0); DavePhos In toluene at 90℃;
1009344-73-3

N-(4-Bromo-2-chloro-6-methylphenyl)-3,3-dimethyl butanamide

799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

1009344-39-1

N-[2-chloro-4-(6-fluoro-3,4-dihydro-1H-isoquinolin-2-yl)-6-methylphenyl]-3,3-dimethylbutanamide

Conditions
ConditionsYield
With potassium tert-butylate; bis(dibenzylideneacetone)-palladium(0); DavePhos In toluene at 90℃;
799274-08-1

6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

24424-99-5

di-tert-butyl dicarbonate

tert-butyl 6-fluoro-3,4-dihydroisoquinoline-2(1H)-carboxylate

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran; water at 20℃; for 18h;

6-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride Specification

The 6-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride, with the CAS registry number 799274-08-1, is also known as Isoquinoline, 6-fluoro-1,2,3,4-tetrahydro-, hydrochloride. This chemical's molecular formula is C9H10FN.HCl and molecular weight is 187.64. What's more, its systematic name is 6-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride (1:1).

You can still convert the following datas into molecular structure:
(1)SMILES: c1cc2c(cc1F)CCNC2.Cl
(2)Std. InChI: InChI=1S/C9H10FN.ClH/c10-9-2-1-8-6-11-4-3-7(8)5-9;/h1-2,5,11H,3-4,6H2;1H
(3)Std. InChIKey: YXZXFMKDFFJUCA-UHFFFAOYSA-N

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