89942-63-2Relevant articles and documents
Vanadium pentoxide as a catalyst for regioselective nitration of organic compounds under conventional and nonconventional conditions
Venkatesham,Reddy, K. Rajendar,Rajanna,Veerasomaiah
, p. 921 - 926 (2014/04/03)
Vanadium pentoxide is used as an efficient catalyst for regioselective nitration of aromatic compounds under conventional and nonconventional conditions such as ultrasonically assisted (USAR) and microwave-assisted reactions (MWAR). The reactions underwent smoothly and afforded good yields of products with high regioselectivity. Observed longer reaction times (about 8 h) in V2O5 catalyzed reactions reduced to (0.5/30 min) under sonication and (90 s) in the case of MWAR. When ortho position is blocked, para derivatives are obtained as end products while ortho nitro products are obtained when para position is blocked.
Topoisomerase I-mediated antiproliferative activity of 10-substituted and 12-substituted homocamptothecins
Guo, Wei,Liu, Wenfeng,Zhu, Lingjian,Zhang, Yongqiang,Cheng, Pengfei,Dong, Guoqiang,Zhuang, Chunlin,Yao, Jianzhong,Sheng, Chunquan,Miao, Zhenyuan,Zhang, Wannian
experimental part, p. 1539 - 1549 (2011/11/05)
Homocamptothecin (hCPT) is an E-ring modified camptothecin (CPT) analogue, which showed pronounced inhibitory activity of topoisomerase I. In search of novel hCPT-type anticancer agents, two series of hCPT derivatives were synthesized and evaluated in vitro against three human tumor cell lines. The results indicated that the 10-substituted hCPT derivatives had a considerably higher cytotoxic activity than the 12-substituted ones. Among the 10-substituted compounds, 8a, 8b, 9b, and 9i showed an equivalent or even more potent activity than the positive control drug topotecan against the lung cancer cell line A-549. Moreover, the hCPT analogues 8a and 8b exhibited a higher topoisomerase I inhibitory activity than CPT at a concentration of 100 μM. Copyright
Design, synthesis, photochemical properties and cytotoxic activities of water-Soluble caged L-Leucyl-L-leucine methyl esters that control apoptosis of immune cells
Mizuta, Hironori,Watanabe, Soichiro,Sakurai, Yuji,Nishiyama, Keiko,Furuta, Toshiaki,Kobayashi, Yoshiro,Iwamura, Michiko
, p. 675 - 683 (2007/10/03)
L-Leucyl-L-leucine methyl esters (LeuLeuOMe) is a lysosomotropic agent that induces apoptosis of certain immune cells. Glucose-carrying 2-nitrobenzyl (2-NB) and 2-nitrophenethyl (2-NPE) caged LeuLeuOMe, 1a and b, were synthesized and their photochemical a
