54903-54-7

Usage

Preparation

Preparation from 6-acetyl-2-(3H)-benzoxazolinone by alkaline hydrolysis with boiling 10% aqueous sodium hydroxide solution (90–100%).

InChI:InChI=1/C8H9NO2/c1-5(10)6-2-3-7(9)8(11)4-6/h2-4,11H,9H2,1H3

Upstream product

• 89942-63-2 1-(5-hydroxy-4-nitrophenyl)ethanone 
• 54903-09-2 6-acetyl-3H-benzooxazol-2-one 
• 59-49-4 2-Benzoxazolinone 
• 95-55-6 2-amino-phenol 

Downstream Products

• 84330-84-7 7-acetyl-3,4-dihydro-2H-1,4-benzoxazin-3-one 
• 1363159-52-7 1-(4-amino-3-n-butoxyphenyl)ethanone 
• 1363159-55-0 1-(4-amino-3-cyclohexyloxyphenyl)ethanone 
• 1363159-59-4 N-(4-acetyl-2-cyclohexyloxyphenyl)methanesulfonamide 
• 1363159-53-8 1-(4-amino-3-n-pentoxyphenyl)ethanone 
• 1363159-57-2 N-(4-acetyl-2-pentoxyphenyl)methanesulfonamide 
• 1363159-54-9 1-(4-amino-3-n-hexoxyphenyl)ethanone 
• 1363159-58-3 N-(4-acetyl-2-hexoxyphenyl)methanesulfonamide 
• 1363159-56-1 N-(4-acetyl-2-butoxyphenyl)methanesulfonamide 

Relevant academic research and scientific papers

HMOX1 inducers

The present invention is related to compounds of structure (I) as heme oxygenase 1 (HMOX 1) inducers. The present invention is also related a method of controlling the activity or the amount, or both the activity and the amount, of heme-oxygenase 1 in a mammalian subject. The definitions of the variables are provided herein.

Synthesis, evaluation and docking studies on 3-alkoxy-4-methanesulfonamido acetophenone derivatives as non ulcerogenic anti-inflammatory agents

A series of 3-alkoxy-4-methanesulfonamido acetophenone derivatives were synthesized and evaluated for their anti-inflammatory activity in carrageenan-induced rat paw edema model. The synthesized compounds were also investigated for their gastric ulcerogenic potential. The compounds 4a, 4c and 4d showed comparable anti-inflammatory activity to rofecoxib and indomethacin, the standard drugs taken in both studies and were also non ulcerogenic at the test doses. In silico (docking studies) were done to investigate the hypothetical binding mode of the target compounds to the cyclooxygenase isoenzyme (COX-2). A binding model has been proposed based on the docking studies. Selected physicochemical properties were calculated for theoretical ADME profiling of the compounds and excellent compliance was shown with Lipinski's rules.

Unequivocal Preparation of 4- and 5-Acyl-2-aminophenols

Unequivocal methods for the specific preparation of 4- or 5-acyl-2-aminophenols are reported. 5-Acyl-2-aminophenols are obtained by ring opening with dilute sodium hydroxide of 2(3H)-benzoxazolinones acylated at position 6. 4-Acyl-2-aminophenols are obtai