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  • 100-90-3 Structure
  • Basic information

    1. Product Name: sulfamethazine-n4-acetyl
    2. Synonyms: acetylsulfadimidine;4'-[(4,6-Dimethyl-2-pyrimidinyl)sulfamoyl]acetanilide;N-[4-[[(4,6-Dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]acetamide;N4-Acetylsulfadimidine;N4-Acetylsulmet
    3. CAS NO:100-90-3
    4. Molecular Formula: C14H16N4O3S
    5. Molecular Weight: 320.36700
    6. EINECS: N/A
    7. Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Sulfur & Selenium Compounds
    8. Mol File: 100-90-3.mol
    9. Article Data: 1
  • Chemical Properties

    1. Melting Point: 249-251°C
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.3086 (rough estimate)
    6. Refractive Index: 1.6270 (estimate)
    7. Storage Temp.: Refrigerator
    8. Solubility: N/A
    9. Water Solubility: 929.1mg/L(37 oC)
    10. CAS DataBase Reference: sulfamethazine-n4-acetyl(CAS DataBase Reference)
    11. NIST Chemistry Reference: sulfamethazine-n4-acetyl(100-90-3)
    12. EPA Substance Registry System: sulfamethazine-n4-acetyl(100-90-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 100-90-3(Hazardous Substances Data)

100-90-3 Usage

Description

Sulfamethazine-n4-acetyl, also known as N4-acetylsulfamethazine, is a metabolite of the antibiotic sulfamethazine. It is a sulfonamide that is benzenesulfonamide substituted by an acetylamino group at position 4 and a 4,6-dimethyl-pyrimidin-2-yl group at the nitrogen atom. It is an off-white solid.

Uses

Used in Pharmaceutical Industry:
Sulfamethazine-n4-acetyl is used as a metabolite of the antibiotic sulfamethazine for various applications in the pharmaceutical industry. It can be used for research and development purposes to understand the metabolism and pharmacokinetics of sulfamethazine, which can help in the design of new drugs and drug delivery systems.
Used in Environmental Monitoring:
Sulfamethazine-n4-acetyl can be used as a biomarker for the detection and monitoring of sulfamethazine residues in the environment. This can help in assessing the environmental impact of sulfamethazine and other related antibiotics, as well as in the development of strategies for their removal or reduction.
Used in Analytical Chemistry:
Sulfamethazine-n4-acetyl can be used as a reference compound in analytical chemistry for the development and validation of analytical methods for the detection and quantification of sulfamethazine and its metabolites. This can be useful in quality control, regulatory compliance, and research applications.
Used in Toxicology Studies:
Sulfamethazine-n4-acetyl can be used in toxicology studies to investigate the potential toxic effects of sulfamethazine and its metabolites on various biological systems. This can help in understanding the safety profile of sulfamethazine and in the development of safer and more effective drugs.
Used in Drug Metabolism Research:
Sulfamethazine-n4-acetyl can be used in drug metabolism research to study the metabolic pathways and enzymes involved in the biotransformation of sulfamethazine. This can provide valuable insights into the factors that influence drug metabolism and can help in the optimization of drug therapy and dosing regimens.

Check Digit Verification of cas no

The CAS Registry Mumber 100-90-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 0 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 100-90:
(5*1)+(4*0)+(3*0)+(2*9)+(1*0)=23
23 % 10 = 3
So 100-90-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H16N4O3S/c1-9-8-10(2)16-14(15-9)18-22(20,21)13-6-4-12(5-7-13)17-11(3)19/h4-8H,1-3H3,(H,17,19)(H,15,16,18)

100-90-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N4-acetylsulfamethazine

1.2 Other means of identification

Product number -
Other names N(4)-acetylsulfamethazine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100-90-3 SDS

100-90-3Downstream Products

100-90-3Relevant articles and documents

The metabolism of four sulphonamides in cows

Nielsen

, p. 1039 - 1045 (1973)

The metabolism of sulphanilamide, sulphadimidine (4,6 dimethyl 2 sulphanilamido pyrimidine), sulphamethoxazole (5 methyl 3 sulphanilamidoisoxazole) and sulphadoxine (5,6 dimethoxy 4 sulphanilamidopyrimidine) given by intravenous injection has been examined in cows. The sulphonamides were present mainly as unchanged drugs in blood samples collected 2 hr after administration. The sulphonamides were excreted in the milk partly as unchanged drugs and partly as conjugated metabolites whereas only small amounts were excreted as the N4 acetyl derivatives. The unchanged drug and the N4 acetyl derivative were the major constituents in urine samples after administration of sulphanilamide, sulphamethoxazole and sulphadoxine. Besides the unchanged drug, the N4 acetyl derivative and the conjugated metabolites, three further metabolites of sulphadimidine were isolated from urine samples and identified. They were 5 hydroxy 4,6 dimethyl 2 sulphanilamidopyrimidine, 4 hydroxymethyl 6 methyl 2 sulphanilamido pyrimidine and sulphaguanidine.

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