1000056-64-3

Upstream product

• 7042-71-9 4-benzyloxyindole-3-carbaldehyde 
• 98-09-9 benzenesulfonyl chloride 
• 20289-26-3 4-benzyloxy-1H-indole 

Relevant academic research and scientific papers

Polymeric micellar delivery of novel microtubule destabilizer and hedgehog signaling inhibitor for treating chemoresistant prostate cancer

Castration-resistant prostate cancer that has become resistant to docetaxel (DTX) represents one of the greatest clinical challenges in the management of this malignancy. There is an urgent need to develop novel therapeutic agents to overcome chemoresista

Fused [d]pyridazin-7-ones

The present invention is directed to fused [d]pyridazin-7-ones. The invention is also directed to methods for making and using the fused [d]pyridazin-7-ones. In particular, the compounds of the present invention may be effective in the treatment of diseases or disease states related to the activity of VEGFR2, MLK1 and CDK5 enzymes, including, for example, angiogenic disorders and neurodegenerative diseases.