1000063-81-9Relevant academic research and scientific papers
THERAPEUTIC COMPOUNDS
-
, (2018/07/06)
no abstract published
Bismacrocyclic inhibitors of hepatitis C NS3/4a protease
McCauley, John A.,Rudd, Michael T.,Nguyen, Kevin T.,McIntyre, Charles J.,Romano, Joseph J.,Bush, Kimberly J.,Varga, Sandor L.,Ross III, Charles W.,Carroll, Steven S.,DiMuzio, Jillian,Stahlhut, Mark W.,Olsen, David B.,Lyle, Terry A.,Vacca, Joseph P.,Liverton, Nigel J.
supporting information; experimental part, p. 9104 - 9107 (2009/02/08)
(Chemical Equation Presented) Double time: The bismacrocycle 2 was prepared from 1 by a selective double ring-closing metathesis (RCM) reaction to form the 18- and 15-membered rings simultaneously. Derivative 3 shows excellent potency against NS3/4a protease.
