81051-55-0

Upstream product

• 6998-30-7 methylamine acetate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 74-89-5 methylamine 
• 98-86-2 acetophenone 
• 60-29-7 diethyl ether 

Downstream Products

• 53256-32-9 (E)-4-[1-Methylamino-1-phenyl-meth-(Z)-ylidene]-pent-2-enedioic acid diethyl ester 
• 55404-27-8 N-methyl-3-etoxycarbonyl-2-phenyl-Δ²-pyrroline-4,5-dione 
• 914834-73-4 ethyl (2Z)-3-[(4-bromo-3-methoxyphenyl)amino]-3-phenylacrylate 
• 1037824-82-0 (Z)-ethyl 2-(3,4,6-tri-O-benzyl-2-deoxy-2-nitro-β-D-glucopyranosyl)-3-(methylamino)-3-phenylacrylate 
• 39629-54-4 (S)-ethyl 3-(methylamino)-3-phenylpropanoate 
• 1000063-81-9 ethyl 3-[(4-bromo-3-methoxyphenyl)amino]-3-phenylacrylate 
• 1397258-04-6 ethyl 1-methyl-2-oxo-6-phenyl-4-trifluoromethyl-1,2-dihydropyrimidine-5-carboxylate 
• 914835-02-2 7-methoxy-2-phenyl-6-vinylquinolin-4(1H)-one 
• 914834-87-0 6-bromo-7-methoxy-2-phenylquinolin-4(1H)-one 
• 159188-35-9 5,6,7-trimethoxy-2-phenyl-4(1H)-quinolone 
• 159188-33-7 5,7-dimethoxy-2-phenylquinoline-4(1H)-one 
• 69888-75-1 3-N-methyl-3-phenyl-propanol 

Relevant academic research and scientific papers

Electrochemical Oxidative Cyclization: Synthesis of Polysubstituted Pyrrole from Enamines

A conceptually novel method for the preparation of pyrrole is described by electrochemical-oxidation-induced intermolecular annulation via enamines. In a simple undivided cell, based on a sodium acetate-facilitated, polysubstituted pyrrole derivations has been facilely synthesized under external oxidant-free condition. This electrosynthetic approach providing an environmentally benign protocol for C?C bond cross-coupling and oxidative annulation, which features unparalleled broad scope of substrates and practicality.

Synthesis of Functionalized Imidazolium Salts via Iodine-Mediated Annulations of Enamines

A novel annulation reaction of two enamine molecules with iodine under basic conditions to form 4-functionalized imidazolium salts has been established. In this reaction, iodine acts as both an iodinating reagent and a Lewis acid catalyst. Features of this synthetic method include facilitative preparation of substrates, no use of transition metals, mild reaction conditions, simplicity of operation, and gram scale synthesis.

THERAPEUTIC COMPOUNDS

no abstract published

Synthesis of chiral β-amino acid derivatives by asymmetric hydrosilylation with an imidazole derived organocatalyst

The organocatalysed asymmetric hydrosilylation of a number of N-aryl and alkyl β-substituted enamino esters proceeds in generally good yield and enantioselectivity. Crucial to obtaining high yield and selectivity was the addition of benzoic acid as an additive and under these conditions, both N-alkyl and N-aryl substituents were well tolerated. β-Aryl and alkyl substituents were evaluated and a model proposed to account for the experimental observations based upon enamine tautomerisation and conformational preferences of the reactive ketimine intermediate.

Bismacrocyclic inhibitors of hepatitis C NS3/4a protease

(Chemical Equation Presented) Double time: The bismacrocycle 2 was prepared from 1 by a selective double ring-closing metathesis (RCM) reaction to form the 18- and 15-membered rings simultaneously. Derivative 3 shows excellent potency against NS3/4a protease.

HCV NS3 PROTEASE INHIBITORS

The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

HCV NS3 PROTEASE INHIBITORS

The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections. I

A chemical evidence of reiochemistry in the Diels-Alder reaction of 4- oxygenated quinolinequinones with 1-methoxy-3-trimethylsilyloxy- 1,3- butadienes

The synthesis of four regioisomeric azaanthraquinones (4a, b and 5a, b) was achieved in a regioselective manner by the Diels-Alder reaction of 4- oxygenated 6-bromo- and 7-bromoquinolinequinones (11 and 15) with 1-methoxy- 3-trimethylsilyloxy-1,3-butadien

Dioxopyrrolines. XXVII. Syntheses of 2-Aryl-3-ethoxycarbonyl-Δ2-pyrroline-4,5-diones

2-Aryl-3-ethoxycarbonyl-Δ2-pyrroline-4,5-diones (3) were easily prepared in good yields by condensation of enamino-esters (2) with oxalyl chloride.The products were characterized by ultraviolet and infrared spectroscopy. Keywords - Δ2-pyrroline-4,5-dione; dioxopyrroline; enamino-ester; ethyl 3-aryl-3-aminopropenoate; 2-aryl-3-ethoxycarbonyl-Δ2-pyrroline-4,5-dione; UV; restricted rotation

OXIDATION OF ENAMINE-ESTERS WITH LEAD TETRA-ACETATE - PART 3. β-AMINOCINNAMATES AND β-AMINOCROTONATES

Oxidation of β-aminocinnamates and β-aminocrotonates with lead tetra-acetate gives fully substituted pyrrole-3,4-diesters.