100009-01-6

Usage

InChI:InChI=1/C15H13N3O3/c1-21-14(19)8-17-15(20)12-6-10-9-4-2-3-5-11(9)18-13(10)7-16-12/h2-7,18H,8H2,1H3,(H,17,20)

Upstream product

• 74214-63-4 β-carboline-3-carboxylic acid 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 69954-48-9 methyl 9H-β-carboline-3-carboxylate 
• 100009-00-5 methyl-β-carboline-3-carboxylate hydrogen oxalate 
• 616-34-2 methoxycarbonylmethylamine 
• 42438-90-4 3-carboxy-1,2,3,4-tetrahydro-2-carboline 
• 73-22-3 L-Tryptophan 

Downstream Products

• 110672-96-3 (S)-2-(2-{2-[(9H-β-Carboline-3-carbonyl)-amino]-acetylamino}-acetylamino)-3-phenyl-propionic acid 
• 110672-93-0 (S)-2-(2-{2-[(9H-β-Carboline-3-carbonyl)-amino]-acetylamino}-acetylamino)-3-phenyl-propionic acid methyl ester 
• 110672-97-4 (S)-2-[(S)-2-(2-{2-[(9H-β-Carboline-3-carbonyl)-amino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid methyl ester 

Relevant academic research and scientific papers

Novel β-carboline/hydroxamic acid hybrids targeting both histone deacetylase and DNA display high anticancer activity via regulation of the p53 signaling pathway

A novel series of hybrids from β-carboline and hydroxamic acid were designed and synthesized. Several compounds (5m, 11b-d, and 11h) not only exerted significant antiproliferation activity against four human colorectal cancer (CRC) cell lines but also sho

β-Carbolines as benzodiazepine receptor ligands. II: Synthesis and benzodiazepine receptor affinity of β-carboline-3-carboxylic acid amides

Numerous β-carboline-3-carboxamides were synthesized by amidation of β-carboline-3-carboxylic acid, with various amino acids and amino acid esters serving as amine components, and tested in respect to their affinity for the benzodiazepine in mouse brain membranes. The title compounds have affinities in the low micromolar range. The results are discussed with respect to their relevance for a possible β-carboline structure containing the endogenous ligand of the benzodiazepine receptor.