1000296-74-1 Usage
Uses
Used in Pharmaceutical Industry:
Chloromethyl 2-ethoxy-2-methylpropanoate is used as a reagent in the synthesis of pharmaceuticals for its ability to introduce the chloromethyl group into organic molecules, which can be crucial for the development of new drug candidates with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, chloromethyl 2-ethoxy-2-methylpropanoate is utilized as a reagent in the synthesis of agrochemicals, where the introduction of the chloromethyl group can enhance the effectiveness of these compounds in agricultural applications.
Used in Fine Chemicals Production:
Chloromethyl 2-ethoxy-2-methylpropanoate is employed as a reagent in the production of fine chemicals, where its versatile reactivity and ability to introduce the chloromethyl functionality are valuable for creating specialty chemicals with specific applications.
Safety Note:
It is important to handle chloromethyl 2-ethoxy-2-methylpropanoate with care due to its corrosive nature, which can cause skin and eye irritation. Proper safety measures should be taken during its use to minimize potential hazards.
Check Digit Verification of cas no
The CAS Registry Mumber 1000296-74-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,0,2,9 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1000296-74:
(9*1)+(8*0)+(7*0)+(6*0)+(5*2)+(4*9)+(3*6)+(2*7)+(1*4)=91
91 % 10 = 1
So 1000296-74-1 is a valid CAS Registry Number.
1000296-74-1Relevant academic research and scientific papers
Development of a practical and efficient synthesis of chloromethyl 2-ethoxy-2-methylpropanoate
Ragan, John A.,Ide, Nathan D.,Cai, Weiling,Cawley, James J.,Colon-Cruz, Roberto,Kumar, Rajesh,Peng, Zhihui,Vanderplas, Brian C.
, p. 1402 - 1406 (2011/09/20)
An efficient synthesis of chloromethyl 2-ethoxy-2-methylpropanoate from 2-bromoisobutyric acid is reported. Four developments were key to this route: (i) a mild, base-mediated ethanolysis of a tertiary alkyl bromide, (ii) a sodium bisulfite purge of 2-methylacrylic acid, (iii) preparation of a thiomethyl ester via a formal Pummerer process with DMSO, and (iv) improved conversion of a thiomethyl ester to a chloromethyl ester through suppression of a competing chlorination pathway.
PENEM PRODRUGS
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Page/Page column 19, (2008/06/13)
Orally bioavailable prodrugs of sulopenem, e.g., and solvates and hydrates thereof, preparation thereof, formulation thereof, and use to treat and prevent infection in mammals such as humans. This abstract is not limiting to the invention.
