1000296-74-1 Usage
General Description
Chloromethyl 2-ethoxy-2-methylpropanoate is a chemical compound that is used as a reagent in organic synthesis. It is a chloromethyl ester, which means it contains a chlorine atom and a carboxylic acid ester group. The ethoxy and methyl groups in the compound contribute to its solubility and reactivity in various organic solvents. It is often utilized in the production of pharmaceuticals, agrochemicals, and other fine chemicals due to its versatile reactivity and ability to introduce the chloromethyl functionality into organic molecules. However, it is important to handle this compound with care, as it is corrosive and can cause skin and eye irritation.
Check Digit Verification of cas no
The CAS Registry Mumber 1000296-74-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,0,2,9 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1000296-74:
(9*1)+(8*0)+(7*0)+(6*0)+(5*2)+(4*9)+(3*6)+(2*7)+(1*4)=91
91 % 10 = 1
So 1000296-74-1 is a valid CAS Registry Number.
1000296-74-1Relevant articles and documents
Development of a practical and efficient synthesis of chloromethyl 2-ethoxy-2-methylpropanoate
Ragan, John A.,Ide, Nathan D.,Cai, Weiling,Cawley, James J.,Colon-Cruz, Roberto,Kumar, Rajesh,Peng, Zhihui,Vanderplas, Brian C.
, p. 1402 - 1406 (2011/09/20)
An efficient synthesis of chloromethyl 2-ethoxy-2-methylpropanoate from 2-bromoisobutyric acid is reported. Four developments were key to this route: (i) a mild, base-mediated ethanolysis of a tertiary alkyl bromide, (ii) a sodium bisulfite purge of 2-methylacrylic acid, (iii) preparation of a thiomethyl ester via a formal Pummerer process with DMSO, and (iv) improved conversion of a thiomethyl ester to a chloromethyl ester through suppression of a competing chlorination pathway.
