1000536-33-3

Usage

Uses

Used in Pharmaceutical Industry:
4-(2-Hydroxyethyl)-alpha,alpha-dimethylphenyl-acetic acid methyl ester is used as a pharmaceutical compound for its potential therapeutic applications. Its diverse functional groups may allow for interactions with various biological targets, suggesting possible uses in drug development and treatment of certain conditions.
Used in Chemical Research:
In the field of chemical research, 4-(2-Hydroxyethyl)-alpha,alpha-dimethylphenyl-acetic acid methyl ester serves as a subject of study for understanding the effects of different functional groups on a molecule's properties. This can contribute to the advancement of organic chemistry and the discovery of new compounds with specific characteristics.
Used in Material Science:
4-(2-Hydroxyethyl)-alpha,alpha-dimethylphenyl-acetic acid methyl ester may be utilized in material science for the development of new materials with unique properties. Its hydrophobic and aromatic features, along with its ester group, could be exploited in the creation of novel polymers, coatings, or other materials with specific applications.
Used in Environmental Applications:
4-(2-Hydroxyethyl)-alpha,alpha-dimethylphenyl-acetic acid methyl ester could be employed in environmental applications, such as in the development of biodegradable materials or in the remediation of contaminated sites. Its properties may allow it to interact with pollutants or serve as a component in eco-friendly products.

Upstream product

• 31469-15-5 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene 
• 4654-39-1 4-bromophenethanol 
• 67-56-1 methanol 
• 552301-45-8 2-methyl-2-[4'-(2''-hydroxyethyl)phenyl]propanoic acid 
• 74-88-4 methyl iodide 
• 547-63-7 Methyl isobutyrate 
• 1145780-83-1 2-(4-isobutyrylphenyl)ethyl acetate 
• 103-45-7 acetic acid phenethyl ester 
• 154825-97-5 methyl 2-(4-bromophenyl)-2,2-dimethylacetate 
• 1298022-54-4 methyl 2-methyl-2-(4-vinylphenyl)propanoate 

Downstream Products

• 1181267-32-2 methyl 2-methyl-2-(4-(2-(methylsulfonyloxy)ethyl)phenyl)propanoate 
• 1181267-30-0 methyl 2-methyl-2-(4-{2-[(4-methylbenzenesulfonyl)oxy]ethyl}phenyl)propanoate 
• 1181267-38-8 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester 
• 202189-78-4 Bilastine 
• 1181267-37-7 2-(4-{2-[4-(1H-benzoimidazol-2-yl)-piperidin-1-yl]-ethyl}phenyl)-2-methyl-propionic acid methyl ester 

Relevant academic research and scientific papers

Preparation method of bilastine intermediate

The invention relates to a preparation method of a bilastine intermediate represented by a formula 1. The preparation method specifically comprises: carrying out a reaction in a first solvent in the presence of DBU by using 2-bromoethyl anisole (formula I

Synthesis method of bilastine intermediate

The invention relates to a synthesis method of a bilastine intermediate. The synthesis method comprises the following steps: S1, carrying out a Friedel-Crafts reaction on phenethyl acetate and isobutyryl halide under catalysis of Lewis acid to generate an intermediate compound B; S2, hydrolyzing the intermediate compound B to remove ester groups under an alkaline or acidic condition to obtain an intermediate compound C; S3, carrying out a hydroxyl protection reaction on the intermediate compound C to obtain an intermediate compound D by adding benzyl or p-methoxybenzyl protection groups to theintermediate compound C; S4, carrying out a bromination reaction on the intermediate compound D to generate an intermediate compound E; S5, carrying out a rearrangement reaction on the intermediate compound E under catalysis of a metal reagent to generate an intermediate compound F; and S6, carrying out hydrogenation or oxidative deprotection on the intermediate compound F to generate a target compound bilastine intermediate methyl alpha,alpha-dimethyl-4-(2-hydroxyethyl)phenylacetate. The method provided by the invention has low raw material cost and simple requirements on equipment and experimental conditions, can realize industrial production, and has a high application value.

A 2 - methyl - 2' - phenyl propanoic acid derivatives of preparation method and its intermediate (by machine translation)

The invention relates to a 2 - methyl - 2' - phenyl propionic acid derivatives preparation method and intermediate thereof, the method is simple and efficient, less side reaction, high yield, low cost, and is suitable for industrial production. (by machin

Alternative synthesis of bilastine

A new and efficient synthesis of the non-sedating histamine H1 receptor antagonist Bilastine is reported. The new route employs a convergent strategy, with a longest linear sequence of five steps, giving slightly improved yields over the previous routes.

PROCESS FOR THE PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS

The present invention relates to a process for preparing 2-methyl-2′-phenylpropionic acid derivatives showing antihistamine activity in more simplified way, intermediate compounds and their preparation processes used therefor. According to the present inv

PROCESS FOR PREPARATION OF 2-METHYL-2′-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS

The present invention relates to a process for preparing 2-methyl-2'-phenylpropionic acid derivatives showing antihistamine activity in more simplified way, intermediate compounds and their preparation processes used therefor. According to the present inv