10006-87-8

Usage

Indole Derivative

1H-Indole, 1-(2-phenylethyl)is a derivative of the indole class of heterocyclic compounds, meaning that it is a modified version of the parent compound indole.

Phenylethyl Group

1H-Indole, 1-(2-phenylethyl)- has a phenylethyl group attached to the nitrogen atom at position 1, which consists of a phenyl ring (a six-membered carbon ring with a hydrogen atom replaced by a hydroxyl group) attached to an ethyl group (two carbon atoms connected by a single bond).

Pharmacological and Biological Activities

1H-Indole, 1-(2-phenylethyl)has been found to have potential pharmacological and biological activities, including antifungal, antibacterial, and anticancer properties.

Treatment of Neurological Disorders

1H-Indole, 1-(2-phenylethyl)- has been studied for its potential use in the treatment of various neurological disorders, indicating that it may have therapeutic effects on the nervous system.

Natural Product Component

1-(2-phenylethyl)-1H-indole has been identified as a component of certain natural products, indicating that it may be found in nature or derived from natural sources.

Fragrance and Flavor Industry

1H-Indole, 1-(2-phenylethyl)- has been investigated for its potential role in the fragrance and flavor industry, suggesting that it may have desirable sensory properties.

Upstream product

• 120-72-9 indole 
• 60-12-8 2-phenylethanol 
• 100-42-5 styrene 
• 122-78-1 phenylacetaldehyde 

Downstream Products

• 134903-48-3 N-(2-phenylethyl)-indole-3-carboxaldehyde 

Relevant academic research and scientific papers

Olefin-Oriented Selective Synthesis of Linear and Branched N-Alkylated Heterocycles by Hydroamination

An effective base-induced selective approach for the synthesis of linear and branched N-alkylated heterocycles by hydroamination of olefins has been described. The designed C–N bond formation method was directed through the olefin, as with styrenes only linear N-alkylated product was obtained, and acrylates gave linear as well as branched alkylated heterocycles. This protocol provided the synthesis of exclusive N-alkylated product instead of the C-3 Michael addition product. The reaction was also compatible with phenyl vinyl sulfone, thus leading to the formation of sulfone substituted heterocycles in good yield. Further, the method was utilized for the synthesis of medicinally important analogs of CB1 Cannabinoid receptor and Dimebon analogue in short reaction sequence.

Selective N-alkylation of indoles with primary alcohols using a pt/HBEA catalyst?

Pt-loaded HBEA (H+-exchanged BEA zeolite) is found to be an effective and reusable heterogeneous catalyst for regioselective N-alkylation of indoles with primary aliphatic and benzylic alcohols under additive-free conditions driven by the borrowing-hydrogen methodology. Structural and mechanistic studies suggest a cooperative mechanism of the Pt0 site on Pt metal clusters and the Br?nsted acid site of the zeolite, in which the Pt0 site is responsible for dehydrogenation/hydrogenation steps and the Br?nsted acid site is responsible for the regioselective condensation of indoles with aldehydes to the enamine intermediate.

Selective ruthenium-catalyzed N-alkylation of indoles by using alcohols

(Chemical Equation Presentation) Alcohols for alkylation! The first homogeneous-catalyzed N-alkylations of indoles with aliphatic alcohols proceed under transfer hydrogenation conditions. By the use of the Shvo catalyst and p-toluenesulfonic acid (PTSA) t