1000672-86-5

Basic information

• Product Name: (E)-2-(2-cyanostyryl)-3,5,6-trimethylpyrazine
• Synonyms: (E)-2-(2-cyanostyryl)-3,5,6-trimethylpyrazine
• CAS NO: 1000672-86-5
• Molecular Weight: 249.315
• Mol File: 1000672-86-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-2-(2-cyanostyryl)-3,5,6-trimethylpyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-(2-cyanostyryl)-3,5,6-trimethylpyrazine(1000672-86-5)
• EPA Substance Registry System: (E)-2-(2-cyanostyryl)-3,5,6-trimethylpyrazine(1000672-86-5)

Safety Data

• Hazardous Substances Data: 1000672-86-5(Hazardous Substances Data)

Upstream product

• 79074-43-4 (3,5,6-trimethylpyrazin-2-yl)methyl acetate 
• 75907-74-3 2-Pyrazinemethanol,3,5,6-trimethyl 
• 612-13-5 2-cyanobenzyl chloride 
• 22978-83-2 2,3,5,6-tetramethylpyrazine mono N-oxide 
• 186534-02-1 3,5,6-trimethyl-pyrazine-2-carbaldehyde 
• 23973-65-1 2-cyano-benzylphosphonic acid diethyl ester 
• 1124-11-4 Tetramethylpyrazine 

Relevant articles and documents

Ligustrazine Derivatives. Part 4: Design, Synthesis, and Biological Evaluation of Novel Ligustrazine-based Stilbene Derivatives as Potential Cardiovascular Agents

A series of novel stilbene derivatives containing ligustrazinyl moiety was designed, synthesized, and assayed for their protective effects on damaged endothelial cells. The results showed that most ligustrazinyl stilbene derivatives exhibited high protective effects on the human umbilical vascular endothelial cells (HUVECs) damaged by hydrogen peroxide in comparison with Ligustrazine. The stilbene derivatives A6, A9, A11, A21, A24, A25, and A27 exhibited high potency with low EC50 values ranged from 0.0249μm to 0.0898mm. Compound A27 displayed EC50 0.0249μm, which is 30000 times higher than that of Ligustrazine, presenting a most promising lead for further investigation. Structure-activity relationships were briefly discussed.