1000682-95-0Relevant academic research and scientific papers
Rose Bengal catalysed photo-induced selenylation of indoles, imidazoles and arenes: A metal free approach
Saba, Sumbal,Rafique, Jamal,Franco, Marcelo S.,Schneider, Alex R.,Espíndola, Leandro,Silva, Dagoberto O.,Braga, Antonio L.
, p. 880 - 885 (2018)
In this report, the highly efficient Rose Bengal-catalysed C(sp2)-H selenylation of indoles, imidazoles and arenes was achieved using a half molar equiv. of diorganoyl diselenides. This metal-free, photo-induced protocol resulted in selenylated
Fe(III)-Catalyzed direct C3 chalcogenylation of indole: The effect of iodide ions
Luz, Eduardo Q.,Seckler, Diego,Araújo, Janylson Souza,Angst, Leonardo,Lima, David B.,Maluf Rios, Elise Ane,Ribeiro, Ronny R.,Rampon, Daniel S.
, p. 1258 - 1266 (2019/02/03)
A mild and efficient iron (III)-catalyzed C3 chalcogenylation of indoles has been developed and the role of the iodide ions in this transformation was investigated. EPR experiments revealed the reduction of Fe(III) to Fe(II) under the reaction conditions, supporting the formation of molecular iodine in the system, which in effect catalyze the reaction. The scope of the chalcogenylation was broad and the synthesis of more functionalized 3-selenylindoles was explored.
Direct selenation of imidazoheterocycles and indoles with selenium powder in a copper-catalyzed three-component one-pot system
Guo, Tao,Dong, Zhe,Zhang, Panke,Xing, Weiqin,Li, Liping
supporting information, p. 2554 - 2558 (2018/05/28)
An efficient and convenient Cu-catalyzed three-component reaction is described for the selenation of imidazoheterocycles/indoles with Se powder and aryl iodides. This procedure provides diverse 3-arylselenylimidazoheterocycles and 3-arylselenylindoles with good yields and functional group tolerance. Some of the products exhibited better or comparable antiproliferative activities compared with the positive control 5-fluorouracil against H1975, PC-9, HGC-27, EC-109, and MCF-7 cancer cell lines.
Preparation method of 3-arylseleno-1H-indoles
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Paragraph 0050; 0051, (2018/06/26)
The invention provides a preparation method of 3-arylseleno-1H-indoles. Specifically, corresponding 3-arylseleno-1H-indoles are generated from aromatic heterocyclic compounds and symmetric diselenidesthrough a reaction in an organic solvent under irradiation of a blue LED lamp, preferably, the reaction is performed in presence of FIrPic (bis(4,6-difluorophenylpyridinato-N,C2)picolinatoiridium). The preparation method is simple and convenient to operate, a reagent is obtained easily, a catalyst is safe and pollution-free, the requirement of green chemistry is met, and the catalyst is stable inproperty and high in catalytic efficiency; yield and purity of 3-arylseleno-1H-indoles prepared with the method are both higher.
Visible-light-mediated aerobic selenation of (hetero)arenes with diselenides
Zhang, Qing-Bao,Ban, Yong-Liang,Yuan, Pan-Feng,Peng, Shou-Jiao,Fang, Jian-Guo,Wu, Li-Zhu,Liu, Qiang
supporting information, p. 5559 - 5563 (2017/12/06)
The first visible-light driven aerobic oxidation for the direct selenation of (hetero)arenes has been developed at room temperature, providing an eco-friendly, atom-economical protocol to prepare unsymmetrical selenides from easily accessible diselenides.
Novel Bronsted acid catalyzed three-component alkylations of indoles with N-phenylselenophthalimide and styrenes
Zhao, Xiaodan,Yu, Zhengkun,Xu, Tongyu,Wu, Ping,Yu, Haifeng
, p. 5263 - 5266 (2008/09/17)
(Chemical Equation Presented) Novel and efficient Bronsted acid (p-TsOH) catalyzed inter- and intramolecular Friedel-Crafts alkylations have been developed to synthesize selenated three-component coupling and selenation-cyclization indole derivatives. Chemical removal of the phenylseleno moiety was investigated, and the reaction mechanisms were discussed.
