1000693-79-7Relevant academic research and scientific papers
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination of Diaryl and Sterically Hindered Ketones with Ammonium Salts and H2
Hu, Le' an,Zhang, Yao,Zhang, Qing-Wen,Yin, Qin,Zhang, Xumu
supporting information, p. 5321 - 5325 (2020/02/28)
A Ru-catalyzed direct asymmetric reductive amination of ortho-OH-substituted diaryl and sterically hindered ketones with ammonium salts is reported. This method represents a straightforward route toward the synthesis of synthetically useful chiral primary diarylmethylamines and sterically hindered benzylamines (up to 97 % yield, 93–>99 % ee). Elaborations of the chiral amine products into bioactive compounds and a chiral ligand were demonstrated through manipulation of the removable and convertible -OH group.
Highly Enantioselective Arylation of N,N-Dimethylsulfamoyl-Protected Aldimines Using Simple Sulfur-Olefin Ligands: Access to Solifenacin and (S)-(+)-Cryptostyline II
Jiang, Tao,Chen, Wen-Wen,Xu, Ming-Hua
supporting information, p. 2138 - 2141 (2017/04/27)
With the use of a simple sulfur-olefin ligand, a highly enantioselective rhodium-catalyzed addition of arylboroxines to N,N-dimethylsulfamoyl-protected aldimines has been achieved, allowing access to a broad range of chiral diarylmethylamines in high yields (up to 98%) with uniformly excellent enantioselectivities (up to 99% ee). This catalyst system is also applicable to the arylation of N-tosyl arylimines. By utilizing this method, some biologically active molecules possessing a chiral 1-aryl-1,2,3,4-tetrahydroisoquinoline core such as Solifenacin and (S)-(+)-Cryptostyline II are facilely constructed.
Copper(I)-Catalyzed Asymmetric Pinacolboryl Addition of N-Boc-imines Using a Chiral Sulfoxide - Phosphine Ligand
Wang, Ding,Cao, Peng,Wang, Bing,Jia, Tao,Lou, Yazhou,Wang, Min,Liao, Jian
, p. 2420 - 2423 (2015/05/27)
Highly efficient and enantioselective copper(I)-catalyzed pinacolboryl addition of N-Boc-imines is reported. By using a single chiral sulfoxide-(dialkyl)phosphine (SOP) ligand, both enantiomeric isomers of α-amino boronic esters were obtained through an achiral counteranion switch.
Catalytic asymmetric addition of arylboronic acids to N-Boc imines generated in?situ using C2-symmetric cationic N-heterocyclic carbenes (NHCs) Pd2+ diaquo complexes
Liu, Zhen,Shi, Min
experimental part, p. 2619 - 2623 (2010/05/17)
The catalytic asymmetric addition of arylboronic acids to N-Boc imines generated in situ from stable and easily prepared α-carbamoyl sulfones was realized by using chiral cationic C2-symmetric N-heterocyclic carbene (NHC) Pd2+ diaquo
Catalytic enantioselective addition of arylboronic acids to N-Boc imines generated in situ
Nakagawa, Hiroshi,Rech, Jason C.,Sindelar, Robert W.,Ellman, Jonathan A.
, p. 5155 - 5157 (2008/09/17)
(Chemical Equation Presented) The rhodium-catalyzed addition of arylboronic acids to N-Boc imines generated in situ from stable and easily prepared α-carbamoyl sulfones has been developed. High enantioselectivities are observed for additions of arylboroni
