1000700-92-4 Usage
Description
O1-benzoyl-β-D-glucopyranuronic acid methyl ester, also known as Bz-GlcAOMe, is a methyl ester derivative of glucuronic acid that plays a significant role in the extracellular matrix of animals. It is characterized by its ability to interact with enzymes that modify carbohydrate structures, making it a crucial component in various biological processes.
Uses
Used in Research and Enzyme Activity Studies:
Bz-GlcAOMe is utilized as a valuable tool in research, particularly for studying the activity of enzymes that modify the structure of carbohydrates. It aids in understanding the role of carbohydrates in biological processes.
Used in Enzymatic Assays:
O1-benzoyl-β-D-glucopyranuronic acid methyl ester is used as a substrate in enzymatic assays, providing a means to evaluate the activity and function of specific enzymes related to carbohydrate modification.
Used in the Study of Glycosaminoglycans:
Bz-GlcAOMe is particularly useful in studying glycosaminoglycans, which are essential for maintaining the structure and function of connective tissues. It helps researchers understand the role of these complex carbohydrates in various biological processes.
Used in Drug Development:
The chemical can be utilized in the synthesis of glycosaminoglycan-derived compounds with potential therapeutic applications. This makes O1-benzoyl-β-D-glucopyranuronic acid methyl ester a promising candidate for drug development, particularly in the area of connective tissue disorders and related conditions.
Used in Pharmaceutical Industry:
O1-benzoyl-β-D-glucopyranuronic acid methyl ester is used as a key component in the development of drugs targeting carbohydrate-related diseases and conditions, contributing to the advancement of therapeutic options for various health issues.
Used in Biomedical Research:
In the field of biomedical research, Bz-GlcAOMe is employed for its potential applications in understanding the interactions between carbohydrates and other biomolecules, which can lead to the discovery of new therapeutic strategies and treatments for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1000700-92-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,0,7,0 and 0 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1000700-92:
(9*1)+(8*0)+(7*0)+(6*0)+(5*7)+(4*0)+(3*0)+(2*9)+(1*2)=64
64 % 10 = 4
So 1000700-92-4 is a valid CAS Registry Number.
1000700-92-4Relevant articles and documents
An improved chemo-enzymatic synthesis of 1-β-O-acyl glucuronides: Highly chemoselective enzymatic removal of protecting groups from corresponding methyl acetyl derivatives
Baba, Akiko,Yoshioka, Tadao
, p. 9541 - 9549 (2008/03/27)
(Chemical Equation Presented) An improved and widely applicable chemo-enzymatic method for the synthesis of a series of 1-β-O-acyl glucuronides 5a-f has been developed from the corresponding methyl acetyl derivatives 3a-f, which were stereospecifically synthesized from cesium salts of carboxylic acids 1a-f and methyl 2,3,4-tri-O-acetyl-1-bromo-1-deoxy-α-D- glucopyranuronate (2). Chemoselectivity of lipase AS Amano (LAS) in the hydrolytic removal of O-acetyl groups of 3a-f to provide methyl esters 4a-f was influenced by the nature of their 1-β-O-acyl groups; high selectivity was evident only for 3b and 3f. Carboxylesterase from Streptomyces rochei (CSR), newly screened as an alternative to LAS, showed much greater chemoselectivity toward the O-acetyl groups than LAS; 3a, 3d, and 3e were chemoselectively hydrolyzed only by CSR. The combination of CSR with LAS yielded better results in the hydrolysis of 3c and 3f than did single usage of CSR. Final deprotection of the methyl ester groups of 4a-f to provide 5a-f was chemoselectively achieved by using lipase from Candida antarctica type B (CAL-B) as well as esterase from porcine liver (PLE), although CAL-B possessed higher chemoselectivity and catalytic efficiency than did PLE. CSR also exhibited high chemoselectivity in the synthesis of (S)-naproxen 1-β-O-acyl glucopyranoside (7) from its 2,3,4,6-tetra-O-acetyl derivative 6.
