1000774-76-4Relevant academic research and scientific papers
Convergent Versus Divergent Three-Step Synthesis of the First (4-Aminophenoxy)alkanoic Acid-Based Tripodal Melamines
Morar, Cristina,Cost, Lavinia,Lameiras, Pedro,Antheaume, Cyril,Darabantu, Mircea
, p. 1688 - 1695 (2015)
Starting from N-(4-hydroxyphenyl)acetamide (Paracetamol, convergent approach) or from cyanuric chloride in reaction with 4-aminophenol (divergent approach), two synthetic routes toward novel tripodal N-substituted melamines as s-triazine derivatives of (4-aminophenoxy)acetic acid or of 4-(4-aminophenoxy)butyric acid are comparatively defined. The key steps consist of Williamson etherification of N-masked forms of 4-aminophenol and acidic hydrolysis of the N- and/or O-protected (4-aminophenoxy)alkanoic segments.
Hapten, artificial antigens and antibody for detecting phenacetin as well as preparation method and application of hapten, artificial antigens and antibody
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Paragraph 0072; 0081-0087, (2021/08/14)
The invention provides a hapten, artificial antigens and an antibody for detecting phenacetin as well as a preparation method and application of the hapten, the artificial antigens and the antibody. A hapten 1, an artificial antigen 1 and an artificial antigen 2 are prepared, the artificial antigen 2 is used for preparing the specific antibody for detecting phenacetin, and the artificial antigen 1 is used as a coating antigen. The antibody has high-sensitivity and high-specificity recognition capability to phenacetin. The detection limit is 2ng/mL, and the cross reaction rate to structural analogues is lower than 3%. An immunoassay method of phenacetin is established, and the purpose of rapidly and accurately detecting phenacetin in herbal tea and other food is achieved.
Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives
Katsura,Tomishi,Inoue,Sakane,Matsumoto,Morinaga,Ishikawa,Takasugi
, p. 3315 - 3321 (2007/10/03)
In order to find a new class of anti-Helicobacter pylori (H. pylori) agents, a series of 4-[(3-acetamido)phenyl]-2-(substituted guanidino)thiazoles and some structurally rigid analoges were synthesized and evaluated for antimicrobial activity against H. pylori. Among the compounds obtained, high anti-H. pyrori activities were observed in benzyl derivative 34 (MIC = 0.025 μg/mL) and phenethyl derivatives 35 and 36 (MIC = 0.037 μg/mL and 0.017 μg/mL). Though alkyl derivatives generally showed lower activity, the 2-methoxyethyl derivative 28 preserved significant activity (MIC = 0.32 μg/mL) and also exhibited more potent gastric antisecretory activity than ranitidine. Structural restriction by bridging between the thiazole and the phenyl rings with an alkyl chain did not improve the activity in this series.
