10008-12-5

Usage

Uses

Used in Organic Synthesis:
2-methylnaphthalene-1-carbonyl chloride is used as a reagent for the synthesis of various organic compounds due to its ability to react with a wide range of nucleophiles, facilitating the formation of carbonyl compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2-methylnaphthalene-1-carbonyl chloride is used as an intermediate in the synthesis of specific drugs, contributing to the development of new medicinal compounds.
Used in Agrochemical Production:
2-methylnaphthalene-1-carbonyl chloride is employed as a precursor in the production of agrochemicals, aiding in the creation of pesticides and other agricultural chemicals to protect crops.
Used in Specialty Chemicals Production:
2-methylnaphthalene-1-carbonyl chloride is also utilized in the manufacturing of specialty chemicals, where its unique reactivity and properties are harnessed for specific applications in various industries.
Safety Note:
It is crucial to handle 2-methylnaphthalene-1-carbonyl chloride with care due to its corrosive nature, which can cause skin and respiratory irritations upon contact. Proper safety measures should be taken during its use to minimize health risks.

InChI:InChI=1/C12H9ClO/c1-8-6-7-9-4-2-3-5-10(9)11(8)12(13)14/h2-7H,1H3

Upstream product

• 2586-62-1 1-bromo-2-methylnaphtalene 
• 1575-96-8 2-methyl-1-naphthoic acid 

Downstream Products

• 859191-87-0 biphenyl-4-yl-(2-methyl-[1]naphthyl)-ketone 
• 36063-09-9 2-Methyl-1-naphthoamid 
• 55394-87-1 mesityl-(2-methyl-[1]naphthyl)-ketone 
• 39070-86-5 1-p-Hydroxybenzoyl-2-methylnaphthalin 
• 15894-60-7 (4-Hydroxy-3,5-diiodo-phenyl)-(2-methyl-naphthalen-1-yl)-methanone 
• 39105-33-4 (3,5-Dibromo-4-hydroxy-phenyl)-(2-methyl-naphthalen-1-yl)-methanone 
• 158434-29-8 2-[4-(4-tert-Butyl-2-tert-butylcarbamoyl-phenyl)-2-oxo-butyl]-naphthalene-1-carboxylic acid tert-butylamide 
• 215-26-9 1,2:3,4:5,6-tribenzanthracene 
• 4919-69-1 (2-methylnaphthalen-1-yl)(phenyl)methanone 
• 7099-42-5 10,11-dihydro-9H-benzo[a]cyclopent[i]anthracene 
• 7099-43-6 2,3-dihydro-1H-benzo[a]cyclopent[h]anthracene 
• 103244-32-2 ethyl 2-methyl-1-naphthalenecarboxylate 

Relevant academic research and scientific papers

NEUTRAL LXR MODULATORS

The present invention relates to amine, carboxamide or thioamide containing compounds which bind to the liver X receptor (LXRα and/or LXRβ) and act preferably as inverse agonists of LXR. The compounds are of formula (I) wherein rings A-D, substituents Rs

Optimization of isochromanone based urotensin II receptor agonists

A series of novel isochromanone based urotensin II receptor agonists have been synthesized and evaluated for their activity using a functional cell based assay (R-SAT). Several potent and efficacious derivatives were identified with 3-(3,4-dichlorophenyl)-6,7-dimethyl-3-(2-dimethylaminoethyl)isochroman-1-one (28) being the most potent compound showing an EC50-value of 51 nM, thereby being the most potent compound so far within the isochromanone series. In addition, two other heterocyclic systems (isochromanes and tetrahydroisoquinolinones) were investigated and these derivatives were found to be both potent and efficacious. The activity of the isochromane derivatives implies that the carbonyl group of the isochromanone is not necessary for activity. Furthermore it was found that the geometry of the heterocycles was more important for receptor interaction than the composition of the heteroatoms present.

Synthesis and structure-activity relationship of a novel series of aminoalkylindoles with potential for imaging the neuronal cannabinoid receptor by positron emission tomography

A new series of CB1 ligands with high binding affinity (K i = 0.7-100 nM) and moderate lipophilicity (cLogD7.4) in the range of 2.1-4.5 has been synthesized. A structure-activity relationship study demonstrated that for the studied set of aminoalkylindoles, the molecular dipole of the ground state conformation within the series was inversely related to the affinity. The racemic ligand with highest affinity (0.7 nM), 3-(4-fluoronaphthoyl)-1-(N-methylpiperidin-2-ylmethyl)indole, was radiolabeled with 18F. This radioligand specifically labeled CB1 receptors in mouse brain and accumulated in regions of high versus low CB 1 receptor density in a ratio of 1.6. The displaceable radioactivity of one enantiomer in the brains of mice determined in a pretreatment study using the CB1 antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4- dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716) was nearly double that of the race-mate for the same determination; therefore, the active enantiomer is a candidate for PET studies in animals. A pretreatement study for the other enantiomer found no displaceable radioactivity in the same group of mice; this result suggested the enantiomer was inactive.

Structure-based design and synthesis of substituted 2-butanols as nonpeptidic inhibitors of HIV protease: Secondary amide series

The design, synthesis, and crystallographic analysis of protein- inhibitor complexes is described for a novel series of nonpeptidic HIV protease (HIV Pr) inhibitors. Beginning with a cocrystal structure of a Phe- Pro peptidomimetic bound to the HIV Pr, design was initiated that resulted in the substituted 2-butanol compound 8 as the lead compound (K(i) = 24.5 μM, racemic mixture). Modifications on the initial compound were then made on the basis of its cocrystal structure with HIV Pr and inhibition data, resulting in compounds with enhanced potency against the enzyme (compound 18, K(i) = 0.48 μM). These inhibitors were found to bind to the enzyme essentially as predicted on the basis of the original design hypothesis. Stereospecific synthesis of individual enantiomers confirmed the prediction of a binding preference for the S alcohol stereochemistry. Modest antiviral activity was demonstrated for several of the more potent HIV Pr inhibitors in a HIV-1 infected CEM-SS cell line.

Chromatographic Separation of Enantiomers and Barriers to Enantiomerization of Axially Chiral Aromatic Carboxamides

The enantiomers (M) and (P) of a series of similar aromatic carboxamides have been, for the first time, investigated analytically and enriched preparatively by liquid chromatography on triacetylcellulose.Enantiomeric purities (7-99percent), specific rotations, and barriers to rotation about the C(sp2)-C(sp2) bond (87 - 120 kJ/mol, Table 5) were determined.These energies are discussed in terms of the size of ortho substituents and of the buttressing effects by meta substituents.