1000988-05-5

Basic information

• Product Name: 2-benzyl-5-(furan-2-yl)-2H-tetrazole
• Synonyms: 2-benzyl-5-(furan-2-yl)-2H-tetrazole
• CAS NO: 1000988-05-5
• Molecular Weight: 226.238
• Mol File: 1000988-05-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-benzyl-5-(furan-2-yl)-2H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyl-5-(furan-2-yl)-2H-tetrazole(1000988-05-5)
• EPA Substance Registry System: 2-benzyl-5-(furan-2-yl)-2H-tetrazole(1000988-05-5)

Safety Data

• Hazardous Substances Data: 1000988-05-5(Hazardous Substances Data)

Upstream product

• 23650-33-1 5-(furan-2-yl)-2H-tetrazole 
• 100-39-0 benzyl bromide 
• 617-90-3 2-furancarbonitrile 
• 108-88-3 toluene 

Relevant articles and documents

Transition-metal-free direct alkylation of aryl tetrazoles via intermolecular oxidative C-N formation

A transition-metal-free synthetic approach for constructing alkylated aryl tetrazoles has been developed using n-Bu4NI as the catalyst and t-BuOOH as the oxidant. It involves the direct C-N bond formation through sp3 C-H activation. A wide range of benzylic C-H substrates (or alkyl ethers) and aryl tetrazoles undergo this reaction smoothly to deliver the corresponding products in good yields.

Synthesis and evaluation of novel heterocyclic MMP inhibitors

A variety of novel heterocyclic compounds were synthesized and evaluated for MMP inhibition. Broad spectrum inhibition of MMPs 1, 2, 9, and 12 was found with pyridinone-based compounds while N-heterocyclic triazoles and tetrazoles were largely ineffective. A highly selective tetrazole inhibitor for MMP-2 was discovered.