1001179-75-4

Upstream product

• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 
• 109135-06-0 methyl 2-(4-chlorophenyl)-3-hydroxypropanoate 
• 1878-66-6 4-chlorophenylacetic Acid 
• 50415-59-3 methyl 2-(4-chlorophenyl)acrylate 
• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 

Downstream Products

• 1001270-85-4 methyl 3-(4-chlorophenyl)pyrrolidine-3-carboxylate 
• 1001179-78-7 1-(tert-butoxycarbonyl)-3-(4-chlorophenyl)pyrrolidine-3-carboxylic acid 
• 1001270-87-6 1-tert-butyl 3-methyl 3-(4-chlorophenyl)pyrrolidine-1,3-dicarboxylate 

Relevant academic research and scientific papers

HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula (I). Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Formula (I). Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.