50415-59-3

Basic information

• Product Name: methyl 2-(4-chlorophenyl)acrylate
• Synonyms: methyl 2-(4-chlorophenyl)acrylate
• CAS NO: 50415-59-3
• Molecular Weight: 196.633
• Mol File: 50415-59-3.mol
• Article Data: 33

Chemical Properties

• CAS DataBase Reference: methyl 2-(4-chlorophenyl)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(4-chlorophenyl)acrylate(50415-59-3)
• EPA Substance Registry System: methyl 2-(4-chlorophenyl)acrylate(50415-59-3)

Safety Data

• Hazardous Substances Data: 50415-59-3(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 873-73-4 4-n-chlorophenylacetylene 
• 201230-82-2 carbon monoxide 
• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 
• 1878-66-6 4-chlorophenylacetic Acid 
• 34757-14-7 methyl 2-diazopropanoate 
• 637-87-6 1-Chloro-4-iodobenzene 
• 50-00-0 formaldehyd 
• 1679-18-1 4-Chlorophenylboronic acid 
• 553-90-2 Dimethyl oxalate 
• 106-39-8 bromochlorobenzene 
• 292638-85-8 acrylic acid methyl ester 
• 109135-06-0 methyl 2-(4-chlorophenyl)-3-hydroxypropanoate 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 1000985-03-4 methyl 2-(4-chlorophenyl)-3-(isopropylamino)propanoate 
• 1001179-75-4 methyl 1-benzyl-3-(4-chlorophenyl)pyrrolidine-3-carboxylate 
• 1001123-94-9 methyl 2-(4-chlorophenyl)-4-methyl-4-nitropentanoate 
• 1001271-02-8 methyl 3-(tert-butylamino)-2-(4-chlorophenyl)propanoate 
• 1231755-94-4 methyl (2E)-2-(4-chlorophenyl)-3-(4-methoxycarbonylphenyl)acrylate 
• 1000985-04-5 methyl 3-(tert-butoxycarbonyl(isopropyl)amino)-2-(4-chlorophenyl)propanoate 
• 1001179-27-6 potassium 3-(tert-butoxycarbonyl(isopropyl)amino)-2-(4-chlorophenyl)propanoate 
• 1001179-31-2 tert-butyl (S)-3-((S)-4-benzyl-2-oxooxazolidin-3-yl)-2-(4-chlorophenyl)-3-oxopropyl(isopropyl)carbamate 
• 1001179-29-8 tert-butyl (R)-3-((S)-4-benzyl-2-oxooxazolidin-3-yl)-2-(4-chlorophenyl)-3-oxopropyl(isopropyl)carbamate 
• 1001179-33-4 (S)-3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-chlorophenyl)propionic acid 
• 1001270-64-9 tert-butyl ((S)-2-(4-chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)(isopropyl)carbamate 
• 537048-28-5 N-benzyl-3-(4-chlorophenyl)-5-(4-methylphenylsulfonyl)piperidine-2,6-dione 

Relevant articles and documents

Electrochemical oxidative: Z -selective C(sp2)-H chlorination of acrylamides

An electrochemical method for the oxidative Z-selective C(sp2)-H chlorination of acrylamides has been developed. This catalyst and organic oxidant free method is applicable across various substituted tertiary acrylamides, and provides access to a broad range of synthetically useful Z-β-chloroacrylamides in good yields (22 examples, 73% average yield). The orthogonal derivatization of the products was demonstrated through chemoselective transformations and the electrochemical process was performed on gram scale in flow.

Cobalt-Catalyzed Vinylic C-H Addition to Formaldehyde: Synthesis of Butenolides from Acrylic Acids and HCHO

A carboxyl-assisted C-H functionalization of acrylic acids with formaldehyde to give butenolides is described. It is the first time that the addition of an inert vinylic C-H bond to formaldehyde has been achieved via cobalt-catalyzed C-H activation. The unique reactivity of the cobalt species was observed when compared with related Rh or Ir catalysts. γ-Hydroxymethylated butenolides were produced by the treatment of Na2CO3 after the catalytic reaction in one pot.

Palladium-catalyzed intermolecular C-H silylation initiated by aminopalladation

A Pd(ii)-catalyzed intermolecular C-H silylation reaction initiated by aminopalladation has been developed. The C-H bonds were activated by an alkyl Pd(ii) species generated through aminopalladation and then disilylated with hexamethyldisilane to form disilylated indolines as the final products. The reaction provides a new method for the introduction of silyl groups into complex organic molecules.