100134-86-9

Usage

General Description

2,6-Piperidinedione, 3-(4-aminophenyl)-3-methyl- is a chemical compound that belongs to the class of piperidines. It is also known by the trade name Avitriptan. 2,6-Piperidinedione, 3-(4-aminophenyl)-3-methyl- is a central nervous system depressant and has been studied for its potential use in treating neurological disorders. It is also a precursor for the synthesis of other organic compounds. In addition, it is used in the production of pharmaceuticals and agrochemicals. This chemical is known for its ability to modulate neurotransmitter release and to act as a GABA receptor agonist. Overall, 2,6-Piperidinedione, 3-(4-aminophenyl)-3-methyl- has a wide range of applications in various fields, including medicine and industry.

Upstream product

• 100143-44-0 3-methyl-3-(4-nitrophenyl)piperidine-2,6-dione 
• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 
• 3123-54-4 2-methyl-2-phenylpentanedioic acid 
• 2572-92-1 ethyl 4-cyano-4-phenylpentanoate 
• 14149-35-0 (+/-)-3-Methyl-3-phenyl-2,6-piperidinedione 
• 1823-91-2 1-phenylethyl cyanide 
• 140-29-4 phenylacetonitrile 
• 102746-75-8 2-methyl-2-phenyl-pentanedinitrile 
• 183663-74-3 1-benzyloxy-3-methyl-3-(4-nitrophenyl)piperidine-2,6-dione 
• 183663-76-5 1-hydroxy-3-methyl-3-(4-aminophenyl)piperidine-2,6-dione 

Relevant academic research and scientific papers

C3-CARBON LINKED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION

This invention provides Degronimers that have carbon-linked E3 Ubiquitin Ligase targeting moieties (Degrons), which can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

A mild preparation of 2,6-piperidinediones

Substituted glutaric acids reacted with alkyloxyamines in the presence of M-ethyl-N-dimethylaminopropylcarbodiimide hydrochloride to form 1-alkyloxy-2,6-piperidinediones. The protecting group on the nitrogen was easily removed in high yield. This process is exemplified by the preparation of aminoglutethimide.

Aromatase Inhibitors. Synthesis and Evaluation of Mammary Tumor Inhibiting Activity of 3-Alkylated 3-(4-Aminophenyl)piperidine-2,6-diones

The synthesis and biological evaluation of 3-alkyl-substituted 3-(4-aminophenyl)piperidine-2,6-diones as inhibitors of estrogen biosynthesis are described .In vitro compounds 4-14 showed a stronger inhibition of human placental aromatase compared to aminoglutethimide (AG, compound 3), which recently has become used for the treatment of hormone-dependent breast cancer.The most active derivative, compound 10, showed a 93-fold stronger inhibition than AG.With the exception of 5, 7, and 8, all other compounds exhibited similar or decreased inhibition of bovine adrenal desmolase compared to AG.Compounds 4 and 6-12 showed a stronger inhibition of the plasma estradiol concentration of pregnant mare serum gonadotropin (PMSG) primed Sprague-Dawley (SD) rats compared to the parent compound.Compounds 4, 6-8, 10, and 12 inhibited the testosterone-stimulated tumor growth of ovariectomized 9,10-dimethyl-1,2-benzanthracene (DMBA) tumor-bearing SD rats more strongly than AG.Being stronger and more selective inhibitors of the estrogen biosynthesis than AG, some of the newly developed derivatives of AG might be better candidates for the treatment of the hormone-dependent human breast cancer.