14149-35-0

Usage

InChI:InChI=1/C12H13NO2/c1-12(9-5-3-2-4-6-9)8-7-10(14)13-11(12)15/h2-6H,7-8H2,1H3,(H,13,14,15)

Upstream product

• 1135-74-6 (-)-4-Cyano-4-methyl-4-phenyl-butyric acid 
• 1823-91-2 1-phenylethyl cyanide 
• 1135-74-6 (+)-4-Cyano-4-methyl-4-phenyl-butyric acid 
• 15142-74-2 Methyl 4-cyano-4-methyl-4-phenyl-butyrate 
• 140-29-4 phenylacetonitrile 
• 1135-74-6 4-Cyano-4-methyl-4-phenyl-butyric acid 
• 102746-75-8 2-methyl-2-phenyl-pentanedinitrile 
• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 
• 3123-54-4 2-methyl-2-phenylpentanedioic acid 
• 107-13-1 acrylonitrile 

Downstream Products

• 90355-78-5 1,3-Dimethyl-3-phenyl-2,6-piperidinedione 
• 100134-86-9 3-methyl-3-(4-aminophenyl)piperidine-2,6-dione 
• 100143-44-0 3-methyl-3-(4-nitrophenyl)piperidine-2,6-dione 

Relevant academic research and scientific papers

Transition-metal-based Lewis acid and base ambiphilic catalysts of iridium hydride complexes: Multicomponent synthesis of glutarimides

Mutual destruction of reagents in acid-and base-promoted reactions in the same container is now avoidable with the iridium polyhydride complex [IrH5(PiPr3)2] (1), which is an ambiphilic Lewis acid and base catalyst. By using catalyst 1, a three-component reaction of nitriles, olefins, and water proceeds efficiently to give glutarimides, which are pharmacologically important (see scheme).

C3-CARBON LINKED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION

This invention provides Degronimers that have carbon-linked E3 Ubiquitin Ligase targeting moieties (Degrons), which can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

Aromatase Inhibitors. Synthesis and Evaluation of Mammary Tumor Inhibiting Activity of 3-Alkylated 3-(4-Aminophenyl)piperidine-2,6-diones

The synthesis and biological evaluation of 3-alkyl-substituted 3-(4-aminophenyl)piperidine-2,6-diones as inhibitors of estrogen biosynthesis are described .In vitro compounds 4-14 showed a stronger inhibition of human placental aromatase compared to aminoglutethimide (AG, compound 3), which recently has become used for the treatment of hormone-dependent breast cancer.The most active derivative, compound 10, showed a 93-fold stronger inhibition than AG.With the exception of 5, 7, and 8, all other compounds exhibited similar or decreased inhibition of bovine adrenal desmolase compared to AG.Compounds 4 and 6-12 showed a stronger inhibition of the plasma estradiol concentration of pregnant mare serum gonadotropin (PMSG) primed Sprague-Dawley (SD) rats compared to the parent compound.Compounds 4, 6-8, 10, and 12 inhibited the testosterone-stimulated tumor growth of ovariectomized 9,10-dimethyl-1,2-benzanthracene (DMBA) tumor-bearing SD rats more strongly than AG.Being stronger and more selective inhibitors of the estrogen biosynthesis than AG, some of the newly developed derivatives of AG might be better candidates for the treatment of the hormone-dependent human breast cancer.

2,6-Piperidinediones, I: Synthesis of the Racemates and Enantiomers of 3,3-Disubstituted 2,6-Piperidinediones

The synthesis of the racemates and the enantiomers of the 3,3-disubstituted 2,6-piperidinediones 3a-3g is performed in three ways, depending on the C-3 substituents.The 3-cyclohexylpiperidinedione 3h is obtained as racemic and optically active compound by