1137869-87-4

Basic information

• Product Name: methyl 4-amino-2-fluoro-5-methoxybenzoate
• Synonyms: methyl 4-amino-2-fluoro-5-methoxybenzoate
• CAS NO: 1137869-87-4
• Molecular Weight: 199.182
• Mol File: 1137869-87-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl 4-amino-2-fluoro-5-methoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-amino-2-fluoro-5-methoxybenzoate(1137869-87-4)
• EPA Substance Registry System: methyl 4-amino-2-fluoro-5-methoxybenzoate(1137869-87-4)

Safety Data

• Hazardous Substances Data: 1137869-87-4(Hazardous Substances Data)

Upstream product

• 1001345-80-7 2‐fluoro‐5‐methoxy‐4‐nitrobenzoic acid 
• 116465-48-6 2,5‐difluoro‐4‐nitrobenzoic acid 
• 1022947-91-6 methyl 2-fluoro-5-methoxy-4-nitrobenzoate 
• 1001346-91-3 4-amino-2-fluoro-5-methoxy-benzoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 1137869-88-5 (R)-methyl 4-(9-cyclopentyl-7-fluoro-5-methyl-6-oxo-7-vinyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-2-fluoro-5-methoxybenzoate 
• 1201692-49-0 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-2-fluoro-5-methoxy-benzoic acid methyl ester 
• 1613730-97-4 methyl 4-amino-2-fluoro-5-methoxy-3-((trimethylsilyl)ethynyl)benzoate 
• 1613730-96-3 methyl 4-amino-2-fluoro-3-iodo-5-methoxybenzoate 

Relevant articles and documents

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

POLO-LIKE KINASE INHIBITORS

Compounds of the following formula are provided for use with kinases: (I) wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates use