1001345-80-7

Basic information

• Product Name: 2-Fluoro-5-methoxy-4-nitrobenzoic acid
• Synonyms: 2-Fluoro-5-methoxy-4-nitrobenzoic acid
• CAS NO: 1001345-80-7
• Molecular Formula: C₈H₆FNO₅
• Molecular Weight: 215.1353432
• Mol File: 1001345-80-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Fluoro-5-methoxy-4-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-5-methoxy-4-nitrobenzoic acid(1001345-80-7)
• EPA Substance Registry System: 2-Fluoro-5-methoxy-4-nitrobenzoic acid(1001345-80-7)

Safety Data

• Hazardous Substances Data: 1001345-80-7(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 924868-81-5 methyl 2,5-difluoro-4-nitrobenzoate 
• 124-41-4 sodium methylate 
• 116465-48-6 2,5‐difluoro‐4‐nitrobenzoic acid 

Downstream Products

• 1001345-79-4 2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)-4-nitrobenzamide 
• 1137867-66-3 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-2-fluoro-5-methoxy-benzoic acid 
• 1137868-52-0 TAK-960 
• 1351761-44-8 GNE-7915 
• 1022947-91-6 methyl 2-fluoro-5-methoxy-4-nitrobenzoate 
• 1018317-68-4 4-[(5-cyclopentyl-4-ethyl-2-methyl-3-oxo-2,4,5,7,9-pentazabicyclo[4.4.0]deca-6,8,10-trien-8-yl)amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidyl)benzamide 
• 1018318-11-0 4-amino-N-(4-dimethylaminocyclohexyl)-2-fluoro-5-methoxy-benzamide 
• 1001347-08-5 4-amino-N-(1-ethyl-4-piperidyl)-2-fluoro-5-methoxy-benzamide 
• 1001347-29-0 4-amino-2-fluoro-5-methoxy-N-(2-pyrrolidin-1-ylethyl)benzamide 
• 1001346-90-2 4-amino-2-fluoro-5-methoxy-N-[(3R)-1-methylpyrrolidin-3-yl]benzamide 
• 1001345-78-3 4-amino-5-methoxy-2-fluoro-N-(1-methyl-piperidin-4-yl)-benzamide 
• 1214266-01-9 2-fluoro-5-methoxy-4-nitro-N-(4-oxocyclohexyl)benzamide 
• 1001346-91-3 4-amino-2-fluoro-5-methoxy-benzoic acid 

Relevant articles and documents

The tale of proteolysis targeting chimeras (PROTACs) for Leucine-Rich Repeat Kinase 2 (LRRK2)

Here we present the rational design and synthetic methodologies towards proteolysis-targeting chimeras (PROTACs) for the recently-emerged target leucine-rich repeat kinase 2 (LRRK2). Two highly potent, selective, brain-penetrating kinase inhibitors were selected, and their structure was appropriately modified to assemble a cereblon-targeting PROTAC. Biological data show strong kinase inhibition and the ability of the synthesized compounds to enter the cells. However, data regarding the degradation of the target protein are inconclusive. The reasons for the inefficient degradation of the target are further discussed.

INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS

The invention relates to indole carboxamide derivatives of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.

POLO-LIKE KINASE INHIBITORS

Compounds of the following formula are provided for use with kinases: (I) wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates use