1001635-01-3

Basic information

• Product Name: (3S,4S)-3-Amino-4-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS NO: 1001635-01-3
• Molecular Weight: 216.28
• Mol File: 1001635-01-3.mol

Chemical Properties

• CAS DataBase Reference: (3S,4S)-3-Amino-4-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4S)-3-Amino-4-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester(1001635-01-3)
• EPA Substance Registry System: (3S,4S)-3-Amino-4-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester(1001635-01-3)

Safety Data

• Hazardous Substances Data: 1001635-01-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(3S,4S)-3-Amino-4-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester is used as a building block for the synthesis of various pharmaceuticals. Its unique structure and functional groups allow for the creation of a wide range of bioactive compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, (3S,4S)-3-Amino-4-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester is used as an intermediate in the production of various agrochemicals. Its structural diversity and reactivity enable the development of compounds with specific pesticidal, herbicidal, or fungicidal properties.
Used in Fine Chemicals Industry:
(3S,4S)-3-Amino-4-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester is also utilized in the synthesis of fine chemicals, which are high-purity chemicals used in various applications, such as fragrances, dyes, and specialty chemicals. Its versatility and reactivity make it a valuable component in the development of these high-quality products.

Upstream product

• 190792-84-8 (3S,4S)-3-azido-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 183184-52-3 1-((3S,4S)-3-azido-4-hydroxypyrrolidin-1-yl)-2,2,2-trifluoroethan-1-one 
• 164931-85-5 meso-N-trifluoroacetyl-3-pyrroline oxide 
• 372482-12-7 (3R,4S)-3-acetoxy-1-tert-butoxycarbonyl-4-methoxypyrrolidine 
• 148214-86-2 (3R,4S)-3-Hydroxy-4-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 372482-11-6 tert-butyl (3S,4S)-3-hydroxy-4-methoxypyrrolidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 372482-13-8 (3S,4S)-tert-butyl 3-azido-4-methoxypyrrolidine-1-carboxylate 
• 372482-16-1 (3S,4S)-1-tert-butoxycarbonyl-3-(tert-butyldimethylsilyl)oxy-4-hydroxypyrrolidine 

Downstream Products

• 372482-03-6 (3S,4S)-3-methoxy-4-(N-methylammmonio)pyrrolidinium di-p-toluenesulphonate 

Relevant articles and documents

Highly active organocatalysts for asymmetric anti-mannich reactions

Lighten the load! A family of enantiopure 4-oxy-substituted 3-aminopyrrolidines arising from the enantioselective ring-opening of meso-3-pyrroline oxide have been developed as catalysts for the asymmetric, anti-selective Mannich reaction (see scheme; PMP=

Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit

Starting from a hit identified by focused screening, 3-aminopyrrolidine factor Xa inhibitors were designed. The binding mode as determined by X-ray structural analysis as well as the pharmacokinetic behaviour of selected compounds is discussed.

Efficient stereospecific synthesis of (S,S)-3-methoxy-4-methylaminopyrrolidine

Efficient stereospecific synthesis of (S,S)-3-methoxy-4-methylaminopyrrolidine, an important intermediate for a novel quinolone antitumor agent AG-7352 is presented. Starting from either D- or L-tartaric acid, a stereospecific synthesis of the chiral pyrrolidine was achieved via two SN2 displacement reactions. From the results of this synthetic study, the absolute structure of AG-7352 was chemically determined.