148214-86-2

Basic information

• Product Name: trans-3-methoxy-4-hydroxy-1-Boc-Pyrrolidine
• Synonyms: trans-3-methoxy-4-hydroxy-1-Boc-Pyrrolidine;rel-(3R,4R)-3-Hydroxy-4-methoxypyrrolidine-1-carboxylic acid tert-butyl ester;1-pyrrolidinecarboxylic acid, 3-hydroxy-4-methoxy-, 1,1-dimethylethyl ester, (3r,4r)-rel-;tert-butyl trans-3-hydroxy-4-methoxypyrrolidine-1-carboxylate;TRANS-1-BOC-3-HYDROXY-4-METHOXYPYRROLIDINE
• CAS NO: 148214-86-2
• Molecular Formula: C10H19NO4
• Molecular Weight: 217.26216
• Mol File: 148214-86-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 302.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.13±0.1 g/cm3(Predicted)
• PKA: 14.07±0.40(Predicted)
• CAS DataBase Reference: trans-3-methoxy-4-hydroxy-1-Boc-Pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: trans-3-methoxy-4-hydroxy-1-Boc-Pyrrolidine(148214-86-2)
• EPA Substance Registry System: trans-3-methoxy-4-hydroxy-1-Boc-Pyrrolidine(148214-86-2)

Safety Data

• Hazardous Substances Data: 148214-86-2(Hazardous Substances Data)

Upstream product

• 114214-49-2 1-tert-butoxycarbonyl-3,4-epoxypyrrolidine 
• 186393-22-6 rac-tert-butyl (3R,4S)-3,4-dihydroxypyrrolidine-1-carboxylate 
• 74-88-4 methyl iodide 
• 150986-62-2 (3R,4R)-1-N-tert-butyloxycarbonyl-3,4-dihydroxypyrrolidine 
• 372482-16-1 (3S,4S)-1-tert-butoxycarbonyl-3-(tert-butyldimethylsilyl)oxy-4-hydroxypyrrolidine 
• 150986-62-2 S,S-3,4-dihydroxypyrrolidine-1-carboxylic acid tert-butyl ester 
• 67-56-1 methanol 
• 865-34-9 lithium methanolate 
• 73286-70-1 N-(tert-butoxycarbonyl)-3-pyrroline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 372482-11-6 tert-butyl (3S,4S)-3-hydroxy-4-methoxypyrrolidine-1-carboxylate 
• 76-26-6 camphor-10-sulfonic acid 
• 372482-12-7 (3R,4S)-3-acetoxy-1-tert-butoxycarbonyl-4-methoxypyrrolidine 

Relevant articles and documents

TLR2 MODULATOR COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

The present disclosure relates to compounds which modulate the activity of Toll-like receptor (TLR) proteins, including agonists or activators, partial agonists, and antagonists. Of particular interest of compounds that modulate the activity of TLR2, as well as methods of using such compounds to treat cancer and other disorders associated with a TLR2 pathway.

ANTIBACTERIAL BASIC BIAROMATIC DERIVATIVES WITH AMINOALKOXY SUBSTITUTION

The invention relates to antibacterial compounds of formula I wherein R1a, R2a, R2b, R3a, R3b, R4, R5, U1, U2, U3, U4, V1, V2, V3, V4, X and Q and n are as defined in the specification. It further relates pharmaceutical compositions containing these compounds and the uses of these compounds in the manufacture of medicaments for the treatment of bacterial infections. These compounds are useful antimicrobial agents effective against a variety of human and veterinary pathogens including among others Gram-positive and Gram-negative aerobic and anaerobic bacteria.

Efficient stereospecific synthesis of (S,S)-3-methoxy-4-methylaminopyrrolidine

Efficient stereospecific synthesis of (S,S)-3-methoxy-4-methylaminopyrrolidine, an important intermediate for a novel quinolone antitumor agent AG-7352 is presented. Starting from either D- or L-tartaric acid, a stereospecific synthesis of the chiral pyrrolidine was achieved via two SN2 displacement reactions. From the results of this synthetic study, the absolute structure of AG-7352 was chemically determined.