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10017-06-8

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10017-06-8 Usage

General Description

(R)-A-HYDROXY-2-THIOPHENEACETONITRILE is a chemical compound with the formula C6H5NO, also known as (R)-2-thiopheneacetonitrile. It is a chiral compound with a hydroxy group attached to the 2-position of the thiophene ring. (R)-A-HYDROXY-2-THIOPHENEACETONITRILE is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. Its unique structure and properties make it a valuable intermediate for the production of various organic compounds. (R)-A-HYDROXY-2-THIOPHENEACETONITRILE's versatility and reactivity make it a valuable component in the field of organic chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 10017-06-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,0,1 and 7 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 10017-06:
(7*1)+(6*0)+(5*0)+(4*1)+(3*7)+(2*0)+(1*6)=38
38 % 10 = 8
So 10017-06-8 is a valid CAS Registry Number.

10017-06-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name (2R)-Hydroxy(2-thienyl)acetonitrile

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10017-06-8 SDS

10017-06-8Downstream Products

10017-06-8Relevant articles and documents

Stereoselective synthesis of thienyl and furyl analogues of ephedrine

Effenberger, Franz,Eichhorn, Joachim

, p. 469 - 476 (1997)

The stereoselective syntheses of thienyl and furyl analogues of ephedrine starting from (R)- and (S)-cyanohydrins, respectively, are described. Addition of methyl Grignard to the O-trimethylsilyl protected optically active cyanohydrins (R)- and (S)-3 and hydrogenation of the resulting imino intermediates gives the erythro-2-amino alcohols 4 with high diastereoselectivity. Their reductive methylation leads to the enantiomerically pure thiophene analogues (1S,2S)- and (1R,2R)-6a, (1R,2S)- and (1S,2R)-6b as well as to the furan analogues (1S,2S)-6c and (1R,2S)-6d of ephedrine, The biological activity of the new compounds is under investigation.

Purification and characterization of a novel (R)-hydroxynitrile lyase from Eriobotrya japonica (Loquat)

Ueatrongchit, Techawaree,Kayo, Ai,Komeda, Hidenobu,Asano, Yasuhisa,H-Kittikun, Aran

, p. 1513 - 1522 (2008/12/21)

A hydroxynitrile lyase was isolated and purified to homogeneity from seeds of Eriobotrya japonica (loquat). The final yield, of 36% with 49-fold purification, was obtained by 30-80% (NH4)2SO4 fractionation and column chromatography on DEAE-Toyopearl and Concanavalin A Sepharose 4B, which suggested the presence of a carbohydrate side chain. The purified enzyme was a monomer with a molecular mass of 72 kDa as determined by gel filtration, and 62.3 kDa as determined by SDS-gel electrophoresis. The N-terminal sequence is reported. The enzyme was a flavoprotein containing FAD as a prosthetic group, and it exhibited a Km of 161 μM and a k cat/Km of 348 s-1 mM-1 for mandelonitrile. The optimum pH and temperature were pH 5.5 and 40°C respectively. The enzyme showed excellent stability with regard to pH and temperature. Metal ions were not required for its activity, while activity was significantly inhibited by CuSO4, HgCl2, AgNO3, FeCl3, β-mercaptoethanol, iodoacetic acid, phenylmethylsulfonylfluoride, and diethylpyrocarbonate. The specificity constant (kcat/Km) of the enzyme was investigated for the first time using various aldehydes as substrates. The enzyme was active toward aromatic and aliphatic aldehydes, and showed a preference for smaller substrates over bulky one.

Preparation of optically active cyanohydrins using the (S)-hydroxynitrile lyase from Hevea brasiliensis

Schmidt, Michael,Herve, Stephanie,Klempier, Norbert,Griengl, Herfried

, p. 7833 - 7840 (2007/10/03)

Several aliphatic, aromatic and heteroaromatic aldehydes have been converted into the chiral cyanohydrins using the (S) hydroxynitrile lyase from Hevea brasiliensis. The corresponding cyanohydrins were obtained in moderate to good yield and high enantiomeric excess with the exeption of phenyloxyacetaldehyde, benzyloxyacetaldehyde and the pyrrole-, pyridine- and indolealdehydes investigated. In contrast to previously reported results, cinnamaldehyde could be converted into (S)-(-)-2-hydroxy-4-phenyl-(E)-but-3- enenitrile with good selectivity by means of optimized reaction conditions.

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