100184-20-1Relevant academic research and scientific papers
T3P mediated intramolecular rearrangement of o-aminobenzamide to o-ureidobenzonitrile using isothiocyanates
Shamanth, Sadashivamurthy,Nagarakere, Sandhya C.,Sagar, Kunigal S.,Narayana, Yatheesh,Mamatha, Mahesha,Rangappa, Kanchugarakoppal S.,Kempegowda, Mantelingu
supporting information, p. 1197 - 1205 (2021/02/16)
Current work describes the environmentally benign approach for the synthesis of o-ureidobenzonitriles, from o-aminobenzamides and isothiocyanates using T3P. Here, the conversion of thiourea to urea and amide to nitrile take place simultaneously via unprec
I2-Catalyzed transformation of: O -aminobenzamide to o -ureidobenzonitrile using isothiocyanates
Chaithra, Nagaraju,Gurukiran, Mahesha,Lokanath, N. K.,Mamatha, Mahesha,Mantelingu, Kempegowda,Rangappa, Kanchugarakoppal S.,Shamanth, Sadashivamurthy
supporting information, p. 2678 - 2684 (2020/04/17)
The present work describes an unexpected and unique protocol for the iodine catalysed synthesis of o-ureidobenzonitriles using o-aminobenzamides and isothiocyanates via intramolecular rearrangement. The metal-free route achieved here is insensitive to moisture and applicable to the synthesis of a wide variety of o-ureidobenzonitriles with excellent yields even in a scalable fashion.
