100189-71-7Relevant academic research and scientific papers
CYCLOALKYL-CONTAINING CARBOXYLIC ACIDS AND USES THEREOF
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Page/Page column 47-48; 69; 80, (2021/06/26)
The present application discloses a compound of formula (I) or a salt thereof: (I) and compositions comprising such compound or salt thereof. The use of such compound, salt thereof or composition comprising same for treating anemia or leukopenia, fibrosis, cancer, hypertension and/or a metabolic condition in a subject is also disclosed.
COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
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Paragraph 00243, (2018/10/19)
The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
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Paragraph 00617, (2017/04/11)
The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
Enantioselective synthesis of (+)-patulolide C via proline-catalyzed sequential α-aminooxylation and Horner-Wadsworth-Emmons olefination
Sabitha, Gowravaram,Chandrashekhar,Yadagiri,Yadav
scheme or table, p. 3824 - 3826 (2010/08/19)
The enantioselective total synthesis of (+)-patulolide C isolated from Penicillium urticae has been achieved from commercially available 9-decen-1-ol. Jacobsen's kinetic resolution and sequential a-aminooxylation and Horner-Wadsworth-Emmons (HWE) olefinat
An efficient stereoselective synthesis of penaresidin A from (E)-2-protected amino-3,4-unsaturated sulfoxide
Raghavan, Sadagopan,Krishnaiah
supporting information; experimental part, p. 748 - 761 (2010/04/30)
(Chemical Equation Presented) An efficient, modular, asymmetric synthesis of penaresidin A is disclosed. A β-protected amino-γ, δ-unsaturated sulfoxide was prepared by stereoselective addition of the lithio anion of (R)-methyl p-tolyl sulfoxide to an unsa
An investigation of the influence of R on the abilities of the polar monomers CH2CH(CH2)8OR (R = Me, PhCH 2, Ph3C, Me3Si, Ph3Si) to participate in O- rather than η2-co
Stojcevic, Goran,Baird, Michael C.
experimental part, p. 8864 - 8877 (2010/02/16)
Copolymerization of ethylene and propylene with polar monomers of the types CH2CH(CH2)nOH (n = 1-12) in order to introduce polar functionality into the resulting polymers is possible in principle if the hydroxyl groups of
Vicinal diamination of terminal olefins
Pfaendler, Hans Rudolf,Klingl, Alexander
, p. 1486 - 1490 (2007/10/03)
The present publication describes an efficient and mild three-step conversion of a terminal olefin 1 into the corresponding 1,2-diamine 5. The sequence includes: azidoiodination, substitution with NaN3, and catalytic hydrogenolysis. The termina
Total Synthesis of (+)-Muconin
Yoshimitsu, Takehiko,Makino, Toshiyuki,Nagaoka, Hiroto
, p. 1993 - 1998 (2007/10/03)
(+)-Muconin (1), isolated from the leaves of Rollinia mucosa (Jacq.) Baill. (Annonaceae), is a sequential THF/THP-possessing acetogenin that exhibits potent and selective in vitro cytotoxicity toward pancreatic and breast tumor cell lines. In this study,
The first total synthesis of the marine fatty acid (±)-9-methoxypentadecanoic acid: A synthetic route towards mid-chain methoxylated fatty acids
Carballeira, Nestor M.,Miranda, Carlos
, p. 63 - 67 (2007/10/03)
The marine fatty acid (±)-9-methoxypentadecanoic acid was synthesized for the first time in seven steps (7.8% overall yield) starting from commercially available 9-decen-1-ol. The key step in the synthesis was the coupling of pentylmagnesium bromide with 1-benzyloxy-9,10-epoxydecane under 1,5-cyclooctadiene copper (I) chloride catalysis. Nuclear magnetic resonance data are provided for the first time for this type of methoxylated fatty acids and the synthetic approach utilized is of general applicability since it can be used in the synthesis of other mid-chain methoxylated fatty acids. This synthetic methodology should afford sufficient quantities of these fatty acids for biological evaluation. The spectral data obtained for the title compound will also be helpful in subsequent characterizations of other mid-chain methoxylated fatty acids using nuclear magnetic resonance spectroscopy.
Synthesis and Utilization of the Chiral Synthon Methyl 3-O-Benzyl-2,4,6-trideoxy-6-iodo-α-D-erythro-hexopyranoside in the Synthesis of a Potent HMG-CoA Reductase Inhibitor
Prugh, John D.,Rooney, C. Stanley,Deana, Albert A.,Ramjit, Harri G.
, p. 648 - 657 (2007/10/02)
Synthesis of the potent HMG-CoA reductase inhibitor 1a has been achieved by utilizing the chiral synthon 2, which was prepared from methyl α-D-glucopyranoside in 12 steps (6 new).A key step in this sequence, which should have general applicability for the
