10021-77-9Relevant articles and documents
QUINOLYL-CONTAINING COMPOUND AND PHARMACEUTICAL COMPOSITION, AND USE THEREOF
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Paragraph 0529-0530, (2022/02/19)
Provided is a quinolyl-containing compound as shown in general formula (I) or (II) or a pharmaceutically acceptable salt, a solvate, an active metabolite, a polymorph, an isotopic label, or an isomer thereof, and further provided are a pharmaceutical composition comprising the compound and use of the compound and the pharmaceutical composition. The provided compound has a dual molecule function, can serve as multi -target inhibitors of novel tyrosine kinase/histone deacetylase, can simultaneously achieve the effect of two inhibitors, has excellent biological activity and pharmacokinetic properties, and has the application potential particularly in the field of treatment of tumors.
Exploiting enzymatic regioselectivity: A facile methodology for the synthesis of polyhydroxylated hybrid compounds
Magrone, Pietro,Cavallo, Francesco,Panzeri, Walter,Passarella, Daniele,Riva, Sergio
experimental part, p. 5583 - 5590 (2011/02/18)
Polyhydroxylated hybrid molecules have been synthesized using a protocol based on the regioselective acylation of the target compounds with activated dicarboxylic acids catalyzed by Novozym-435. The procedure implies that the mixed ester derivatives prepared and isolated from the first esterification step act as acylating agents in the second esterification step.
Designer ligands. Part 4. Synthesis of acyclic and macrocyclic platinum group metal-specific ligands
Hagemann, Justin P.,Kaye, Perry T.
, p. 341 - 348 (2007/10/03)
Synthetic pathways to a range of novel, polydentate, sulfur-containing, mono-amide ligands, designed to coordinate platinum group metals, have been developed.Access to the tetradentate systems was facilitated by the extensive use of disulfide linkages as a protection strategy.