1047-94-5

Usage

Uses

Used in Rubber Industry:
Acetamide, 2,2'-dithiobis[N-(phenylmethyl)is used as an accelerator for the vulcanization process in the rubber industry. Its fast curing action contributes to the improved heat resistance and aging properties of rubber products, ensuring their durability and performance under various conditions. However, safety guidelines must be followed to minimize the risk of skin, eye irritation, and respiratory issues associated with its use.

Upstream product

• 505-73-7 disulfanediyldiacetic acid 
• 100-46-9 benzylamine 
• 10021-77-9 2,2'-disulfanediyldiacetylchloride 
• 679794-61-7 5-(2-amino-3-pyridyl)-2-ethoxycarbonylthio-3H-1,3,4-oxadiazole 

Downstream Products

• 1009-79-6 N-benzyl-2-mercapto acetamide 
• 1363300-99-5 (2R,3S,4S,5R)-2-[2-(N-benzyl-2-acetamidyl)sulfanyl-ethyl]-3,4,5-trihydroxy-piperidine hydrochloride 

Relevant academic research and scientific papers

β-GLUCOCEREBROSIDASE CHAPERONES

The present application relates to compounds of the Formula (I): which are useful or the treatment of diseases in which the wild type or a mutant form of the enzyme β-glucocerebrosidase is implicated.

Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease

A highly divergent route to lipophilic iminosugars that utilizes the thiol-ene reaction was developed to enable the rapid synthesis of a collection of 16 dideoxyiminoxylitols bearing various different lipophilic substituents. Enzyme kinetic analyses revea

Synthesis and anti-proliferative activity in vitro of new 5-(2-amino-3-pyridyl)-2-thioxo-3H-1,3,4-oxadiazole derivatives

The reaction of 2-aminonicotinic acid hydrazide 1 with carbon disulfide gives 5-(2-amino-3-pyridyl)-2-thioxo-3H-1,3,4-oxadiazole 4 which on treatment with ethyl bromoacetate affords 5-(2-amino-3-pyridyl)-2-ethoxycarbonylthio-1,3,4-oxadiazole 5. Treatment of compound 5 with the appropriate primary and secondary amines provided the corresponding oxadiazole derivatives: alkyl-(cycloalkyl-, aryl)-aminocarbamylmethylthio-6-10 or alkyl-(cycloalkyl-, aryl)-amino-11-16. The reaction of 5 with benzylamine furnishes two products: 5-(2-amino-3-pyridyl)-2-benzylamino-1,3,4-oxadiazole 18 and di (benzylcarbamylmethyl)sulfide 19. Selected compounds are tested for their antiproliferative activity in vitro. One of them 19 reveals cytotoxic activity against the cells of 4 human tumor cell lines applied. The ID50 values are in the range of the international activity criterion for synthetic agents (4 μg/mL).