1047-94-5

Basic information

• Product Name: Acetamide, 2,2'-dithiobis[N-(phenylmethyl)-
• CAS NO: 1047-94-5
• Molecular Formula: C18H20N2O2S2
• Molecular Weight: 360.501
• Mol File: 1047-94-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Acetamide, 2,2'-dithiobis[N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2,2'-dithiobis[N-(phenylmethyl)-(1047-94-5)
• EPA Substance Registry System: Acetamide, 2,2'-dithiobis[N-(phenylmethyl)-(1047-94-5)

Safety Data

• Hazardous Substances Data: 1047-94-5(Hazardous Substances Data)

Usage

General Description

Acetamide, 2,2'-dithiobis[N-(phenylmethyl)-, also known as ZDEC, is a chemical compound commonly used as an accelerator in the production of rubber. It belongs to the family of dithiocarbamate accelerators, which are widely used in the vulcanization process of rubber products. ZDEC is a white powder that is soluble in organic solvents and has a moderate melting point. It is known for its fast curing action, providing improved heat resistance and aging properties to rubber compounds. However, prolonged exposure to ZDEC may cause skin and eye irritation, as well as respiratory issues, making it important to handle with care and follow safety guidelines when using this chemical.

Upstream product

• 505-73-7 disulfanediyldiacetic acid 
• 100-46-9 benzylamine 
• 10021-77-9 2,2'-disulfanediyldiacetylchloride 
• 679794-61-7 5-(2-amino-3-pyridyl)-2-ethoxycarbonylthio-3H-1,3,4-oxadiazole 

Downstream Products

• 1009-79-6 N-benzyl-2-mercapto acetamide 
• 1363300-99-5 (2R,3S,4S,5R)-2-[2-(N-benzyl-2-acetamidyl)sulfanyl-ethyl]-3,4,5-trihydroxy-piperidine hydrochloride 

Relevant articles and documents

β-GLUCOCEREBROSIDASE CHAPERONES

The present application relates to compounds of the Formula (I): which are useful or the treatment of diseases in which the wild type or a mutant form of the enzyme β-glucocerebrosidase is implicated.

Synthesis and anti-proliferative activity in vitro of new 5-(2-amino-3-pyridyl)-2-thioxo-3H-1,3,4-oxadiazole derivatives

The reaction of 2-aminonicotinic acid hydrazide 1 with carbon disulfide gives 5-(2-amino-3-pyridyl)-2-thioxo-3H-1,3,4-oxadiazole 4 which on treatment with ethyl bromoacetate affords 5-(2-amino-3-pyridyl)-2-ethoxycarbonylthio-1,3,4-oxadiazole 5. Treatment of compound 5 with the appropriate primary and secondary amines provided the corresponding oxadiazole derivatives: alkyl-(cycloalkyl-, aryl)-aminocarbamylmethylthio-6-10 or alkyl-(cycloalkyl-, aryl)-amino-11-16. The reaction of 5 with benzylamine furnishes two products: 5-(2-amino-3-pyridyl)-2-benzylamino-1,3,4-oxadiazole 18 and di (benzylcarbamylmethyl)sulfide 19. Selected compounds are tested for their antiproliferative activity in vitro. One of them 19 reveals cytotoxic activity against the cells of 4 human tumor cell lines applied. The ID50 values are in the range of the international activity criterion for synthetic agents (4 μg/mL).