100223-10-7Relevant academic research and scientific papers
SYNTHESIS OF α-AMINO ACID DERIVATIVES BY COPPER(I)-CATALYZED CONJUGATE ADDITION OF GRIGNARD REAGENTS TO METHYL 2-ACETAMIDOACRYLATE
Cardellicchio, C.,Fiandanese, V.,Marchese, G.,Naso, F.,Ronzini, L.
, p. 4387 - 4390 (1985)
The reactions of Grignard reagent with methyl 2-acetamidoacrylate in the presence of CuI give fair to good yields of α-amino esters; the corresponding α-deutero- or α-methyl-derivatives are obtained upon quenching with D+ or CH3I, respectively.
Efficient Access to Alanine Derivatives by 1,4-Additions of Potassium Trifluoro(organo)borates
Navarre, Laure,Darses, Sylvain,Genet, Jean-Pierre
, p. 69 - 73 (2004)
Potassium trifluoro(organo)borates, highly stable and easily prepared organoboran derivatives, were able to react with a great variety of dehydroamino esters. This reaction, catalyzed by rhodium complexes, allowed the formation of alanine derivatives bearing a great variety of amino protecting groups in good to high yields.
Chiral bisphosphine ligands based on quinoline oligoamide foldamers: application in asymmetric hydrogenation
Zheng, Lu,Zheng, Dan,Wang, Yanru,Yu, Chengyuan,Zhang, Kun,Jiang, Hua
, p. 9573 - 9577 (2019/11/20)
A series of chiral bisphosphine ligands were designed and synthesized based on single-handed quinoline oligoamide foldamers. The bisphosphine ligands can coordinate with Rh(cod)2BF4 in a 1 : 1 stoichiometry and the resulted chiral Rh(i) catalysts were applied in the asymmetric hydrogenation of α-dehydroamino acid esters, in which excellent conversions and promising levels of enantioselectivity were achieved.
Axial 4,4′,6,6′-tetrakis-trifluoromethyl-biphenyl-2, 2′diamine (TF-BIPHAM): Resolution and applications in asymmetric hydrogenation
Wang, Chun-Jiang,Gao, Feng,Liang, Gang
supporting information; experimental part, p. 4711 - 4714 (2009/05/31)
(Equation Presented) The racemic TF-BIPHAM was resolved for the first time, and the effectiveness of the resolved diamine was demonstrated by highly enantioselective hydrogenation of α-aryl enamides and α-dehydroamino acid esters using readily accessible
