SYNTHESIS OF α-AMINO ACID DERIVATIVES BY COPPER(I)-CATALYZED CONJUGATE ADDITION OF GRIGNARD REAGENTS TO METHYL 2-ACETAMIDOACRYLATE

Article abstract of DOI:10.1016/S0040-4039(00)98742-2

The reactions of Grignard reagent with methyl 2-acetamidoacrylate in the presence of CuI give fair to good yields of α-amino esters; the corresponding α-deutero- or α-methyl-derivatives are obtained upon quenching with D⁺ or CH3I, respectively.