1002318-89-9Relevant academic research and scientific papers
A General Route to β-Substituted Pyrroles by Transition-Metal Catalysis
Bunrit, Anon,Sawadjoon, Supaporn,T?upova, Svetlana,Sj?berg, Per J. R.,Samec, Joseph S. M.
, p. 1450 - 1460 (2016/03/01)
An atom-efficient route to pyrroles substituted in the β-position has been achieved in four high yielding steps by a combination of Pd, Ru, and Fe catalysis with only water and ethene as side-products. The reaction is general and gives pyrroles substitute
Redox-Neutral Aromatization of Cyclic Amines: Mechanistic Insights and Harnessing of Reactive Intermediates for Amine α- and β-C?H Functionalization
Ma, Longle,Paul, Anirudra,Breugst, Martin,Seidel, Daniel
, p. 18179 - 18189 (2016/12/16)
Cyclic amines such as pyrrolidine and piperidine are known to undergo condensations with aldehydes to furnish pyrrole and pyridine derivatives, respectively. A combined experimental and computational study provides detailed insights into the mechanism of pyrrole formation. A number of reactive intermediates (e.g., azomethine ylides, conjugated azomethine ylides, enamines) were intercepted, outlining strategies for circumventing aromatization as a valuable pathway for amine C?H functionalization.
Sp3 C-H bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines
Sundararaju, Basker,Achard, Mathieu,Sharma, Gangavaram V. M.,Bruneau, Christian
, p. 10340 - 10343 (2011/08/05)
A selective C(3)-alkylation via activation/functionalization of sp 3 C-H bond of saturated cyclic amines was promoted by (arene)ruthenium(II) complexes featuring a bidentate phosphino-sulfonate ligand upon reaction with aldehydes. This highly regioselective sustainable transformation takes place via initial dehydrogenation of cyclic amines and hydrogen autotransfer processes.
Microwave-assisted method for synthesis of 1,3-disubstituted pyrroles
Polackova, Viera,Veverkova, Eva,Toma, Stefan,Bogdal, Dariusz
experimental part, p. 1871 - 1876 (2009/11/30)
1,3-Disubstituted pyrroles were prepared by a microwave-assisted reaction of pyrrolidine and aldehydes in toluene as well as in solvent-free conditions. Reactions were completed in a few minutes in the solvent-free condition but a long time (up to 30min)
A facile non-oxidative method for synthesizing 1,3-disubstituted pyrroles from pyrrolidine and aldehydes
Oda, Mitsunori,Fukuchi, Yosuke,Ito, Satoshi,Thanh, Nguyen Chung,Kuroda, Shigeyasu
, p. 9159 - 9162 (2008/09/18)
Reactions of pyrrolidine with 2 equiv of aldehydes without any catalyst in a pressurized vessel at 140-200 °C yielded 1,3-disubstituted pyrroles. α-Branched aldehydes gave fairly good yields of the corresponding products by this method, which provides a f
