100240-05-9

Basic information

• Product Name: N-PHENYL-3-PIPERIDINAMINE
• Synonyms: N-PHENYL-3-PIPERIDINAMINE;3-phenylaminopiperidine;3-Piperidinamine, N-phenyl-
• CAS NO: 100240-05-9
• Molecular Formula: C11H16N2
• Molecular Weight: 176.26
• Product Categories: pharmacetical
• Mol File: 100240-05-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 312 °C at 760 mmHg
• Flash Point: 185.3 °C
• Appearance: /
• Density: 1.052 g/cm³
• Vapor Pressure: 0.000543mmHg at 25°C
• Refractive Index: 1.578
• PKA: 9.35±0.10(Predicted)
• CAS DataBase Reference: N-PHENYL-3-PIPERIDINAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-PHENYL-3-PIPERIDINAMINE(100240-05-9)
• EPA Substance Registry System: N-PHENYL-3-PIPERIDINAMINE(100240-05-9)

Safety Data

• Hazardous Substances Data: 100240-05-9(Hazardous Substances Data)

Usage

General Description

N-Phenyl-3-Piperidinamine is a chemical compound utilized in the process of creating a variety of products in the pharmaceutical and chemical industries. This white to off-white solid compound has the molecular formula C11H14N2, and is generally used as an intermediate in the synthesis of other chemicals. Its stability, reactivity, and potential toxicity are dependent on the conditions under which it is stored and used. Proper handling and storage are crucial to maintaining its efficacy and safety. More research is needed to fully understand its potential health effects and environmental impact.

InChI:InChI=1/C11H16N2/c1-2-5-10(6-3-1)13-11-7-4-8-12-9-11/h1-3,5-6,11-13H,4,7-9H2

Upstream product

• 5024-68-0 Phenyl-pyridin-3-yl-amine 
• 108-90-7 chlorobenzene 
• 144243-24-3 tert‐butyl 3‐aminopiperidine‐1‐carboxylate 
• 108-86-1 bromobenzene 
• 54012-73-6 3-aminopiperidine 
• 591-50-4 iodobenzene 
• 127294-75-1 3-amino-piperidine dihydrochloride 
• 183207-67-2 1-(tert-butoxycarbonyl)-3-(phenylamino)piperidine 

Relevant articles and documents

B(C6F5)3-Catalyzed Cascade Reduction of Pyridines

B(C6F5)3 has been found to be an effective catalyst for reduction of pyridines and other electron-deficient N-heteroarenes with hydrosilanes (or hydroboranes) and amines as the reducing reagents. The success of this development hinges upon the realization of a cascade process of dearomative hydrosilylation (or hydroboration) and transfer hydrogenation. The broad functional-group tolerance (e.g. ketone, ester, unactivated olefins, nitro, nitrile, heterocycles, etc.) implies high practical utility.

Palladium-mediated N-arylation of heterocyclic diamines: Insights into the origin of an unusual chemoselectivity

The chemoselectivity of the palladium-mediated reaction of bromobenzene with various heterocyclic diamines was studied. Whatever the ligand used, 3-aminopyrrolidine underwent arylation of the secondary amine function (> 82%), whereas the more flexible 3-aminoazepinine was arylated on its primary function (>70%). The ratio "arylation of primary amine versus arylation of secondary amine" of 3-aminopiperidine with bromobenzene varied from 90:10 (BINAP, electron-enriched and hindered biphenyls L2 or L3) to 32:68 with the Josiphos-type ligand L10. The same trend was observed when 4-aminopiperidine was used (82:18 with L2 and 17:83 with L10). This selectivity can be tuned by the choice of aryl halide partners having different steric and electronic properties. A cooperative effect of both nitrogens of diamines during the reaction was deduced from competitive experiments. Finally, 13C and 31P NMR experiments, carried out with 3-aminopyrrolidine at room temperature, support a fast coordination of the primary amine to the metal. Indeed, a palladium complex resulting from the unusual displacement of one phosphane group of the intermediate ArPdX(BINAP) by the primary amino group was characterized.

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