127294-75-1

Basic information

• Product Name: 3-PIPERIDINAMINE HYDROCHLORIDE
• Synonyms: 3-Piperidinylamine dihydrochloride
• CAS NO: 127294-75-1
• Molecular Formula: C₅H₁₂N₂*2ClH
• Molecular Weight: 0
• Mol File: 127294-75-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-PIPERIDINAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PIPERIDINAMINE HYDROCHLORIDE(127294-75-1)
• EPA Substance Registry System: 3-PIPERIDINAMINE HYDROCHLORIDE(127294-75-1)

Safety Data

• Hazardous Substances Data: 127294-75-1(Hazardous Substances Data)

Usage

General Description

3-Piperidinamine Hydrochloride is a chemical compound predominantly utilized in the pharmaceutical industry for drug development. It is an amine compound that includes the piperidine functional group. Its hydrochloride salt form enhances its solubility in water, making it easy to manage and use in various applications. It is commonly referenced by its Chemical Abstracts Service (CAS) number, 6859-99-0. This substance can be harmful if swallowed or in contact with skin or eyes and should be handled with the appropriate safety measures. Specific applications may involve its use as a chemical reagent in the synthesis of other complex organic compounds.

Upstream product

• 71962-74-8 Ethyl nipecotate 
• 689758-90-5 piperidine-3-carboxylic acid hydrazide 
• 1622856-04-5 piperidine-3-carboxylic acid hydrazide monohydrochloride 
• 184637-48-7 t-butyl piperidin-3-ylcarbamate 
• 397246-12-7 (1,5-dihydroxypent-2-yl)carbamic acid tert-butyl ester 
• 861658-15-3 1,5-dimethyl 2-[(t-butoxycarbonyl)amino]pentanedioate 
• 617-65-2 Glutamic acid 
• 6525-53-7 glutamic acid dimethyl ether 
• 4138-26-5 nipecotamide 
• 1353094-64-0 N-acetyl-3-aminopiperidine acetate 
• 1352756-67-2 N-acetyl-3-aminopyridine acetate 
• 462-08-8 pyridin-3-ylamine 

Downstream Products

• 63921-21-1 3-amino-1-phenylpiperidine 
• 100240-05-9 3-(phenylamino)piperidine 
• 956468-14-7 N-(1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-3-piperidinyl)-3,4-bis(methyloxy)benzenesulfonamide 
• 485820-18-6 2-(8-(3-aminopiperidin-1-yl)-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurin-7-ylmethyl)benzonitrile trifluoroacetate 
• 485820-41-5 8-(3-aminopiperidin-1-yl)-7-(2-bromobenzyl)-1,3-dimethyl-3,7-dihydropurine-2,6-dione trifluoroacetate 
• 1352756-66-1 (R)-piperidine-3-amine dibenzoyl-D-tartrate 
• 334618-23-4 3-(R)-aminopiperidine dihydrochloride 
• 190654-14-9 6-(3-chloro-phenyl-amino)-9-ethyl-2-(3-formylamino-piperidin-1-yl)-9H-purine 
• 668271-78-1 1,3-dimethyl-7-(2,6-dicyano-benzyl)-8-(3-amino-piperidin-1-yl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine 
• 842135-73-3 isoquinoline-5-sulphonic acid piperidin-3-ylamide 
• 940907-93-7 2-((2-(3-aminopiperidin-1-yl)-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile 

Relevant articles and documents

Synthetic process of anti-hyperglycemic drug intermediate R-3-amino-piperidine dihydrochloride

The invention relates to a synthetic process of an anti-hyperglycemic drug intermediate R-3-amino-piperidine dihydrochloride. The synthetic process comprises the steps: using inexpensive L-glutamic acid as a starting material, and performing esterification, amino protection, reduction, hydroxyl protection, substitution, cyclization and removal of protecting groups for amino groups so as to obtainthe R-3-amino-piperidine dihydrochloride. Compared with the prior art, the synthetic process has cheap and easily available raw materials, good selectivity, good atomic economy, high total yield and mild reaction conditions, and is suitable for industrial production.

PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED 3-AMINOPIPERIDINE

The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, and in particular of its R-enantiomer (R)-3-aminopiperidine. The invention also relates to an enantiomerically enriched intermediate of said process and to specific acid-addition salts of 3-aminopiperidine (hereinafter also APIP) that are useful for obtaining a single enantiomer of APIP, and to crystalline (R)-3-aminopiperidine-dihydrochloride-monohydrateand crystalline (S)-3-aminopiperidine-dihydrochloride-monohydrate.

PROCESS FOR THE PREPARATION OF A SINGLE ENANTIOMER OF 3-AMINOPIPERIDINE DIHYDROCHLORIDE

A process comprising: (a) reduction of N-acetyl-3-aminopyridine (2): or its salt in the presence of hydrogen and a palladium catalyst deposited on solid support; (b) converting racemic N-acetyl-3-aminopiperidine (3) or its salt produced in step (a) to rac-3-aminopiperidine (rac-4) or its salt; (c) resolution of the racemic 3-aminopiperidine (rac-4) or its salt produced in step (b) with a chiral acid.