100240-32-2Relevant academic research and scientific papers
Synthesis of New 6-[4-(2-Fluorophenylpiperazine-1-YL)]-3(2H)-Pyridazinone-2-Acethyl-2- (Substitutedbenzal)Hydrazone Derivatives and Evulation of Their Cytotoxic Effects in Liver and Colon Cancer Cell Lines
?zdemir, Zeynep,Ba?ak-Türkmen, Ne?e,Ayhan, ?dris,?ift?i, Osman,Uysal, Mehtap
, p. 923 - 929 (2019)
In this study, seven new 3(2H)-pyridazinone derivatives expected to show cytotoxic activity in liver and colon cancer cell lines were synthesized. Their structures were confirmed by the IR, 1H-NMR, 13C-NMR spectra and elementary anal
Design, synthesis, and biological evaluation of pyridazinones containing the (2-fluorophenyl) piperazine moiety as selective MAO-B inhibitors
?e?en, Muhammed,Oh, Jong Min,?zdemir, Zeynep,Büyüktuncel, Saliha Ebru,Uysal, Mehtap,Abdelgawad, Mohamed A.,Musa, Arafa,Gambacorta, Nicola,Nicolotti, Orazio,Mathew, Bijo,Kim, Hoon
, (2020)
Twelve pyridazinones (T1–T12) containing the (2-fluorophenyl) piperazine moiety were designed, synthesized, and evaluated for monoamine oxidase (MAO) -A and -B inhibitory activities. T6 was found to be the most potent MAO-B inhibitor with an IC50/su
Synthesis, molecular modelling and biological activity of some pyridazinone derivatives as selective human monoamine oxidase-B inhibitors
?zdemir, Zeynep,Alag?z, Mehmet Abdullah,Uslu, Harun,Karakurt, Arzu,Erikci, Acelya,Ucar, Gulberk,Uysal, Mehtap
, p. 692 - 704 (2020/03/11)
Background: Since brain neurotransmitter levels are associated with the pathology of various neurodegenerative diseases like Parkinson and Alzheimer, monoamineoxidase (MAO) plays a critical role in balancing these neurotransmitters in the brain. MAO isofo
Synthesis and antimicrobial, acetylcholinesterase and butyrylcholinesterase inhibitory activities of novel ester and hydrazide derivatives of 3(2H)-pyridazinone
Oezcelik, Azime Berna,Goekce, Mehtap,Orhan, Ilkay,Kaynak, Fatma,Sahin, Mustafa Fethi
scheme or table, p. 452 - 458 (2011/04/25)
In the current study, some novel ethyl 6-[(substituted-phenylpiperazine]- 3(2H)-pyridazinone-2-yl propionate III and 6-[(substituted-phenylpiperazine]- 3(2H)-pyridazinone-2-yl propionohydrazide IV derivatives were synthesized as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. The structures of these new pyridazinone derivatives were confirmed by their IR, 1H-NMR spectra and elementary analysis. 6-Substituted-3(2H)- pyridazinone-2-yl propionate IIIa-e derivatives showed significant inhibitory activity against AChE and BChE. 6-[4-(3-Trifluoromethylphenyl)-piperazine]-3(2H) -pyridazinone-2-yl propionate IIIe has been found to be the most active compound in terms of inhibition of either AChE or BChE. Compound IIIe exhibited inhibitory activity close to that of galantamine (CAS 357-70-0) and did not show any selectivity between the two enzymes. Also the antimicrobial activities of III and IV derivatives have been evaluated. All III and IV derivatives exhibited poor antibacterial activities but moderate antifungal activities. ECV ? Editio Cantor Verlag.
Anti-virally active pyridazinamines
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, (2008/06/13)
Anti-virally active pyridazinamines, compositions containing the same and methods of treating viral diseases in warm-blooded animals.
