1009567-00-3Relevant articles and documents
Synthesis, molecular modelling and biological activity of some pyridazinone derivatives as selective human monoamine oxidase-B inhibitors
?zdemir, Zeynep,Alag?z, Mehmet Abdullah,Uslu, Harun,Karakurt, Arzu,Erikci, Acelya,Ucar, Gulberk,Uysal, Mehtap
, p. 692 - 704 (2020/03/11)
Background: Since brain neurotransmitter levels are associated with the pathology of various neurodegenerative diseases like Parkinson and Alzheimer, monoamineoxidase (MAO) plays a critical role in balancing these neurotransmitters in the brain. MAO isofo
Design, synthesis, and biological evaluation of pyridazinones containing the (2-fluorophenyl) piperazine moiety as selective MAO-B inhibitors
?e?en, Muhammed,Oh, Jong Min,?zdemir, Zeynep,Büyüktuncel, Saliha Ebru,Uysal, Mehtap,Abdelgawad, Mohamed A.,Musa, Arafa,Gambacorta, Nicola,Nicolotti, Orazio,Mathew, Bijo,Kim, Hoon
, (2021/01/12)
Twelve pyridazinones (T1–T12) containing the (2-fluorophenyl) piperazine moiety were designed, synthesized, and evaluated for monoamine oxidase (MAO) -A and -B inhibitory activities. T6 was found to be the most potent MAO-B inhibitor with an IC50/su
Synthesis of New 6-[4-(2-Fluorophenylpiperazine-1-YL)]-3(2H)-Pyridazinone-2-Acethyl-2- (Substitutedbenzal)Hydrazone Derivatives and Evulation of Their Cytotoxic Effects in Liver and Colon Cancer Cell Lines
?zdemir, Zeynep,Ba?ak-Türkmen, Ne?e,Ayhan, ?dris,?ift?i, Osman,Uysal, Mehtap
, p. 923 - 929 (2019/02/19)
In this study, seven new 3(2H)-pyridazinone derivatives expected to show cytotoxic activity in liver and colon cancer cell lines were synthesized. Their structures were confirmed by the IR, 1H-NMR, 13C-NMR spectra and elementary anal
Synthesis and analgesic and anti-inflammatory activity of ethyl (6-substituted-3(2H)-pyridazinone-2-yl)acetate derivatives
Duendar, Yasemin,Goekce, Mehtap,Kuepeli, Esra,Sahin, Mustafa Fethi
, p. 777 - 781 (2008/09/19)
A number of 6-substituted-3(2H)-pyridazinones and the corresponding methyl (6-substituted-3(2H)-pyridazinone-2-yl)acetate derivatives carrying the arylpiperazinyl structure present in potent antinociceptive agents reported in the literature were synthesiz
