10027-80-2

Basic information

• Product Name: (1R,2S)-rel-1,2-Cyclohexanediamine hydrochloride
• Synonyms: (1R,2S)-rel-1,2-Cyclohexanediamine hydrochloride;cis-1,2-Cyclohexanediamine dihydrochloride;(1R,2S)-Cyclohexane-1,2-diaMine dihydrochloride;(1R,2S)-CYCLOHEXANE-1,2-DIAMINE 2HCL
• CAS NO: 10027-80-2
• Molecular Formula: C₆H₁₆N₂*2Cl
• Molecular Weight: 187.11064
• Mol File: 10027-80-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 307-310℃
• Boiling Point: 193.6°Cat760mmHg
• Flash Point: 75°C
• Appearance: /
• Density: 0.939g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (1R,2S)-rel-1,2-Cyclohexanediamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S)-rel-1,2-Cyclohexanediamine hydrochloride(10027-80-2)
• EPA Substance Registry System: (1R,2S)-rel-1,2-Cyclohexanediamine hydrochloride(10027-80-2)

Safety Data

• Hazardous Substances Data: 10027-80-2(Hazardous Substances Data)

Usage

General Description

(1R,2S)-rel-1,2-Cyclohexanediamine hydrochloride is a chemical compound that is used as a reagent in organic synthesis. It is a chiral molecule, meaning it has non-superimposable mirror images. The hydrochloride salt form of the compound makes it more stable and easier to handle in a laboratory setting. (1R,2S)-rel-1,2-Cyclohexanediamine hydrochloride can be used in the preparation of various pharmaceuticals, agrochemicals, and other organic compounds. It has applications in the production of chiral catalysts and ligands, as well as in the synthesis of chiral drugs and natural products. Overall, (1R,2S)-rel-1,2-Cyclohexanediamine hydrochloride is an important building block in organic chemistry and has a wide range of uses in chemical and pharmaceutical industries.

Upstream product

• 32044-22-7 (R,R)-1,2-diaminocyclohexane tartrate 
• 110-83-8 cyclohexene 
• 85782-31-6 (1R,6S)-7-Aza-bicyclo[4.1.0]heptane-7-carboximidic acid ethyl ester 
• 85782-23-6 (trans-2-bromocyclohexyl)cyanamide 
• 95647-96-4 3a,4,5,6,7,7a-hexahydro-2-ethoxybenzimidazole 
• 32044-22-7 (1R,2R)-1,2-diaminocyclohexane tartrate 
• 116407-32-0 (1R,2R)-(-)-1,2-diammoniumcyclohexane mono-L-(+)-tartrate 
• 186144-56-9 N-[(1R,2R)-2-(2-Methoxycarbonyl-acetylamino)-cyclohexyl]-malonamic acid methyl ester 
• 71172-32-2 1,2-dinitrocyclohexane 
• 64162-07-8 2-amino-cyclohexanecarboxylic acid ethyl ester 
• 34126-95-9 2-aminocyclohexanecarboxamide 

Downstream Products

• 215057-24-2 2,2'-(1E,1'E)-(1R,2R)-cyclohexane-1,2-diylbis(azan-1-yl-1-ylidene)bis(methan-1-yl-1-ylidene)diphenol 
• 20439-47-8 (1R,2R)-1,2-diaminocyclohexane 
• 65838-10-0 (1R,2R)-N,N'-dibenzylcyclohexane-1,2-diamine 
• 193824-05-4 (1R,2R)-N,N’-di(2-hydroxybenzyl)-1,2-diaminocyclohexane 
• 1383854-72-5 (R,R)-N,N'-bis[(4-dimethylaminophenyl)methyl]-1,2-cyclohexanediamine 
• 1200403-92-4 (1R,2R)-N₁,N₂-bis(pyridin-3-ylmethyl)cyclohexane-1,2-diamine 
• 96027-57-5 (1R,2R)-N¹-Benzoyl-N²-(2,4-dinitrophenyl)-1,2-cyclohexane diamine 
• 223704-18-5 (R,R)-N,N'-(cyclohexane-1,2-diyl)bis-<3-(p-toluenesulphonylamino)propyl methanesulphonate> 
• 223704-16-3 (R,R)-N,N'-(cyclohexane-1,2-diyl)bis-<3-(p-toluenesulfonylamino)propan-1-ol> 

Relevant articles and documents

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SYNTHESIS OF CYCLIC CARBONATES

A dimeric aluminium(salen) catalyst of formula I: herein: Y-Q is CRC1=N or CRC1RC2-NRN1, where RC1, RC2 and RN1 are independently selected from H, halo, optionally substituted C1-20 alkyl, optionally substituted C5-20 aryl, ether and nitro; each of the substituents R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16, is independently selected from H, halo, optionally substituted C1-20 alkyl, optionally substituted C5-20 aryl, optionally substituted C3-20 heterocyclyl, ether and nitro; X1 and X2 are independently either (i) a C2-5 alkylene chain, which is optionally substituted by one or more groups selected from C1-4 alkyl and C5-7 aryl, or a C1-3 bisoxyalkylene chain, which is optionally substituted by one or more groups selected from C1-4 alkyl and C5-7 aryl or (ii) represent a divalent group selected from C5-7 arylene, C5-7 cyclic alkylene and C3-7 heterocyclylene, which may be optionally substituted; (i) (a) at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16 is selected from L-A, where L is a single bond or a C1-10 alkylene group and A is an ammonium group paired with a counterion selected from Cl, Br and I; and/or (b) at least one of X1 and X2 is a divalent C3-7 heterocyclene group, containing a ring atom which is a quaternary nitrogen atom paired with a counterion selected from Cl, Br and I; and/or (c) at least one of X1 and X2 is a C2-5 alkylene chain or a C1-3 bisoxyalkylene chain, substituted by a group -Q-L-A, where Q is either -C(=O)-O-, -C(=O)-NH-, or a single bond; and/or (ii) (a) one of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16 is L-A', where L is as defined above and A' is a ammonium linking group bound to a solid support and paired with a counterion selected from Cl, Br and I; or (b) one of X1 and X2 is a divalent C3-7 heterocyclene group, containing a ring atom which is a quaternary nitrogen forming part of an ammonium linking group bound to a solid support and paired with a counterion selected from Cl, Br and I; or (c) one of X1 and X2 is a C2-5 alkylene chain or a C1-3 bisoxyalkylene chain, substituted by a group -Q-L-A'.

SYNTHESIS OF CYCLIC CARBONATES IN THE PRESENCE OF DIMERIC ALUMINIUM (SALEN) CATALYSTS

A process for the production of cyclic carbonates comprising contacting an epoxide with carbon dioxide in the presence of a dimeric aluminium(salen) catalyst, and a co-catalyst capable of supplying Y-, where Y is selected from Cl, Br and I, where the dimeric aluminium(salen) catalyst is of formula I: