186144-56-9

Upstream product

• 1121-22-8 trans-1,2-Diaminocyclohexane 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 10027-80-2 (1R,2R)-1,2-dicyclohexane-1,2-diamine dihydrochloride 
• 223704-18-5 (R,R)-N,N'-(cyclohexane-1,2-diyl)bis-<3-(p-toluenesulphonylamino)propyl methanesulphonate> 
• 223704-16-3 (R,R)-N,N'-(cyclohexane-1,2-diyl)bis-<3-(p-toluenesulfonylamino)propan-1-ol> 
• 143585-47-1 (R,R)-1,2-bis(tosylamino)cyclohexane 
• 223704-20-9 (R,R)-N,N'-(cyclohexane-1,2-diyl)bis(2-carbamoylethanamide) 

Relevant academic research and scientific papers

Enantioselective analysis of an asymmetric reaction using a chiral fluorosensor

(Chemical Equation Presented) An axially chiral 1,8-dipyridylnaphthalene N,N′-dioxide has been employed in enantioselective fluorescence analysis of the enzymatic kinetic resolution of trans-1,2-diaminocyclohexane. The procedure eliminates cumbersome purification and derivatization steps required by traditional methods. The results demonstrate the potential of fluorescence spectroscopy using suitable chiral chemosensors for real-time analysis of the enantiomeric composition of chiral compounds and for high-throughput screening of asymmetric reactions.

Sequential biocatalytic resolution of (±)-trans-cyclohexane-1,2-diamine. Chemoenzymatic synthesis of an optically active polyamine

Candida antarctica lipase-catalysed double monoaminolysis of dimethyl malonate by (±)-trans-cyclohexane-1,2-diamine allows the sequential resolution of the latter compound, affording an enantiopure bis(amidoester), (R,R)-3, which is subsequently transformed into an optically active polyamine, (R,R)-9.