100278-53-3

Upstream product

• 100-09-4 4-methoxybenzoic acid 
• 100-07-2 4-methoxy-benzoyl chloride 
• 94-09-7 p-aminoethylbenzoate 
• 100278-51-1 Ethyl-4-(4-methoxybenzoylamino)benzoate 

Downstream Products

• 109633-07-0 C₂₃H₂₂N₄O₃S 
• 100278-35-1 N-{4-[1-(4-Hydroxy-3-methoxy-phenyl)-meth-(Z)-ylidene-hydrazinocarbonyl]-phenyl}-4-methoxy-benzamide 
• 109632-89-5 4-Methoxy-N-{4-[1-methyl-prop-(Z)-ylidene-hydrazinocarbonyl]-phenyl}-benzamide 
• 187274-36-8 C₁₉H₂₀N₄O₃S 
• 187274-37-9 C₂₂H₂₆N₄O₃S 
• 466690-15-3 C₂₃H₂₂N₄O₃S 
• 109660-44-8 N-[4-(4-Benzyl-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl)-phenyl]-4-methoxy-benzamide 
• 109633-21-8 N-[4-(4-Butyl-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl)-phenyl]-4-methoxy-benzamide 

Relevant academic research and scientific papers

Type IIA - Type IIB protein tyrosine kinase inhibitors hybridization as an efficient approach for potent multikinase inhibitor development: Design, synthesis, anti-proliferative activity, multikinase inhibitory activity and molecular modeling of novel ind

Pursuing on our efforts regarding development of novel multikinase inhibitors, herein we report the design and synthesis of novel 2-indolinone-based ureides 6a-u and amides 10a-j. In this work we adopt a hybridization strategy between type IIA PTK inhibit

Synthesis, characterisation and biological activity of novel 4-thiazolidinones, 1,3,4-oxadiazoles and some related compounds

Two novel series of 4-thiazolidinone derivatives namely 2-substituted-3-{[4-(4-methoxybenzoylamino)benzoyl]amino}-4-thiazolidinones (7a-e) and 2-[4-(4-methoxybenzoylamino)benzoylhydrazono]-3-alkyl-4-thiazolidinones (5a-c) together with 2-[4-(4-methoxybenzoylamino)phenyl]-5-(substituted enyl)amino-1,3,4-oxadiazoles (6a-c) have been synthesised as title compounds. N1-[4-(4-methoxybenzoylamino)benzoyl]-N2-substituted methylene hydrazines (3a-e) and 1-[4-(4-methoxybenzoylamino)benzoyl]-4-substituted phenyl thiosemicarbazides (4a-f) were also prepared and used as intermediate to give the title compounds. All synthesised compounds were screened for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv and antimicrobial activities against various bacteria and fungi. Compounds 7a and 7b were found as the most active derivatives demonstrating 90 and 98 percent inhibition of mycobacterial growth of M. tuberculosis H37Rv in the primary screen at 6.25 μg mL-1, respectively. However, level II assay revealed that the MIC values were not less than 6.25 μg mL-1. None of the compounds showed significant antimicrobial activity against the microorganisms used whereas 3a and 7a inhibited the growth of several bacteria and fungi.

Synthesis and antimicrobial activity of some 1,4-disubstituted thiosemicarbazide and 2,5-disubstituted 1,3,4-thiadiazole derivatives

Various new 1,4-disubstituted thiosemicarbazide and 2,5-disubstituted-1,3,4-thiadiazole derivatives were synthesized and evaluated for their in vitro antimicrobial activity. The structure of compounds was confirmed by elemental analyses and spectroscopic