1002948-40-4

Basic information

• Product Name: N-(2-acetylaminoethyl)-3-iodobenzamide
• CAS NO: 1002948-40-4
• Molecular Weight: 332.141
• Mol File: 1002948-40-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-acetylaminoethyl)-3-iodobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-acetylaminoethyl)-3-iodobenzamide(1002948-40-4)
• EPA Substance Registry System: N-(2-acetylaminoethyl)-3-iodobenzamide(1002948-40-4)

Safety Data

• Hazardous Substances Data: 1002948-40-4(Hazardous Substances Data)

Upstream product

• 618-51-9 3-Iodobenzoic acid 
• 1001-53-2 monoacetylaminoethylamine 
• 1711-10-0 3-iodobenzoyl chloride 

Relevant articles and documents

Synthesis and evaluation of iodinated benzamide derivatives as selective and reversible monoamine oxidase B inhibitors

A new series of iodinated analogues of N-(2-aminoethyl)benzamide was synthesized and evaluated for inhibitory potency and specificity toward monoamine oxidase type-B (MAO-B). Among them, N-(2-aminoethyl)-2-chloro-4-iodobenzamide hydrochloride (2d) showed high inhibitory potency and selectivity against MAO-B. The type of MAO-B inhihition by 2d was non-competitive and the inhibition constant (K(i)) was 0.80 μM. Strong and selective in vivo MAO-B inhibition by 2d was also confirmed. The brain MAO-B inhibition by 2d was reversible and the enzyme activity completely returned to the control value 24 h after administration. Compound 2d was, therefore, considered to be a candidate for advanced development as a radioiodinated ligand that may be useful for functional MAO-B studies in the living brain using single photon emission computer tomography.