10031-92-2Relevant articles and documents
Copper(i)/phosphine-catalyzed tandem carboxylation/annulation of terminal alkynes under ambient pressure of CO2: One-pot access to 3a-hydroxyisoxazolo[3,2-a]isoindol-8(3aH)-ones
Xie, Jia-Ning,Yu, Bing,Guo, Chun-Xiang,He, Liang-Nian
, p. 4061 - 4067 (2015)
An efficient method for the synthesis of 3a-hydroxyisoxazolo[3,2-a]isoindol-8(3aH)-ones from CO2, terminal alkynes, EtBr, and NHPI (N-hydroxyphthalimide) was developed through a tandem carboxylation/annulation strategy catalyzed by a copper(i)/phosphine system. This one-pot multicomponent reaction was conducted at atmospheric CO2 pressure to afford the target products in good to excellent yields under mild conditions. Notably, a wide range of functional groups were tolerated in this procedure. This protocol with simultaneous formation of four novel bonds i.e. two C-C bonds and two C-O bonds represents an efficient methodology for upgrading CO2 into heterocycles.
Total synthesis of a piperidine alkaloid, microcosamine A
Raji Reddy, Chada,Latha, Bellamkonda,Warudikar, Kamalkishor,Singarapu, Kiran Kumar
, p. 251 - 258 (2015)
The first asymmetric total synthesis of a new natural piperidine alkaloid, microcosamine A, has been accomplished from d-serine and d-methyl lactate as chiral pool starting materials. Key features of the strategy include the utility of Horner-Wadsworth-Emmons reaction, Luche reduction, intramolecular carbamate N-alkylation to form the piperidine framework and Julia-Kocienski olefination to install the triene side-chain.
An entry to non-racemic β-tertiary-β-amino alcohols, building blocks for the synthesis of aziridine, piperazine, and morpholine scaffolds
Narczyk, Aleksandra,Stecko, Sebastian
supporting information, p. 5972 - 5981 (2020/08/21)
A method for the preparation of enantiopure β-tert-amino alcohols bearing a tetrasubstituted C-stereocenter, as well as their conversion into selected medicinally privileged heterocyclic systems (morpholines, aziridines, piperazines) is reported. These co
