1003314-88-2Relevant academic research and scientific papers
Iridium-Catalyzed Reductive Alkylations of Secondary Amides
Ou, Wei,Han, Feng,Hu, Xiu-Ning,Chen, Hang,Huang, Pei-Qiang
, p. 11354 - 11358 (2018)
Reported herein is the first direct, metal-catalyzed reductive functionalization of secondary amides to give functionalized amines and heterocycles. The method is shown to have exceptionally broad scope with respect to suitable nucleophiles, which cover both hard and soft C nucleophiles as well as a P nucleophile. The reaction exhibits good chemoselectivity and tolerates several sensitive functional groups.
Phenylphosphonic acid as efficient and recyclable catalyst in the synthesis of α-aminophosphonates under solvent-free conditions
Bedolla-Medrano, Mercedes,Hernández-Fernández, Eugenio,Ordó?ez, Mario
, p. 1145 - 1149 (2014/05/20)
Phenylphosphonic acid is an efficient, friendly and reusable heterogeneous catalyst for the synthesis of α-aminophosphonates through a 'one-pot' three-component reaction of amines, carbonyl compounds and dialkyl phosphites under solvent-free conditions. This methodology illustrates a very simple procedure, with wide applicability, extending the scope to aliphatic and aromatic amines, aliphatic and aromatic aldehydes and aliphatic ketones. It also enabled the synthesis of α-aminophosphonates in large scale, clean conversion, easy workup and purification. Excellent results were obtained in each case obtaining the desire compounds in moderate to good yields. Georg Thieme Verlag Stuttgart New York.
PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS
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Page/Page column 127, (2008/06/13)
The present invention relates to a novel class of phosphorus derivatives. The phosphorus compounds can be used to treat cancer. The phosphorus compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differe
