1003599-69-6Relevant articles and documents
Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: An attempt to improve the activity against Mycobacterium tuberculosis
Andaloussi, Mounir,Lindh, Martin,Bj?rkelid, Christofer,Suresh, Surisetti,Wieckowska, Anna,Iyer, Harini,Karlén, Anders,Larhed, Mats
scheme or table, p. 5403 - 5407 (2011/10/12)
Two series of FR900098/fosmidomycin analogs were synthesized and evaluated for MtDXR inhibition and Mycobacterium tuberculosis whole-cell activity. The design rationale of these compounds involved the exchange of either the phosphonic acid or the hydroxamic acid part for alternative acidic and metal-coordinating functionalities. The best inhibitors provided IC50 values in the micromolar range, with a best value of 41 μM.