10036-17-6Relevant academic research and scientific papers
Phosphine-Catalyzed Anti -Hydroboration of Internal Alkynes
Nagao, Kazunori,Yamazaki, Ayaka,Ohmiya, Hirohisa,Sawamura, Masaya
, p. 1861 - 1865 (2018)
Trialkylphosphine organocatalysts have enabled regioselective anti-hydroboration of internal alkynes with pinacolborane reagents to provide (E)-disubstituted alkenylboronate compounds. The alkenylboronate can be used for derivatizations, such as protodebo
Palladium-Catalyzed meta-Selective C-H Functionalization by Noncovalent H-Bonding Interaction
Jin, Zhong,Li, Guoshuai,Xu, Xiaohua,Yan, Yifei,Zhang, Pengfei
, p. 10460 - 10466 (2021/08/31)
Controlling positional selectivity represents one of the most important aspects in transition-metal-catalyzed C-H bond functionalization. However, the conventional directing template strategies via a covalent binding to the substrates are always hindered by prior stoichiometric installation and removal of the directing groups. Herein, we report a palladium-catalyzed meta-selective C-H olefination of aromatic carbonyl compounds by noncovalent hydrogen-bonding interaction. N,N′-Substituted ureas were engineered to serve as a H-bonding donor for binding to the substrates and, meanwhile, achieve site-selective control by the integrated directing group.
S,O-Ligand-Promoted Palladium-Catalyzed C-H Functionalization Reactions of Nondirected Arenes
Naksomboon, Kananat,Valderas, Carolina,Gómez-Martínez, Melania,álvarez-Casao, Yolanda,Fernández-Ibá?ez, M. ángeles
, p. 6342 - 6346 (2017/09/15)
Pd(II)-catalyzed C-H functionalization of nondirected arenes has been realized using an inexpensive and easily accessible type of bidentate S,O-ligand. The catalytic system shows high efficiency in the C-H olefination reaction of electron-rich and electron-poor arenes. This methodology is operationally simple, scalable, and can be used in late-stage functionalization of complex molecules. The broad applicability of this catalyst has been showcased in other transformations such as Pd(II)-catalyzed C-H acetoxylation and allylation reactions.
