100366-83-4Relevant academic research and scientific papers
Dramatic Reversal of Diastereoselectivity in an N-Acyliminium Ion Cyclization Leading to Hexahydropyrroloisoquinolines. A Case of Competing Steric Interactions
Maryanoff, Bruce E.,McComsey, David F.,Almond, Harold R.,Mutter, Martin S.,Bemis, Guy W.,et al.
, p. 1341 - 1346 (2007/10/02)
The N-acyliminium ion cyclization 1 -> 2 + 3 (eq 1) with various aliphatic substituents (R = ethyl, cyclohexyl, and tert-butyl) was carried out, as an extension of our work in ref 2.The following 2:3 ratios were obtained: 39:61, 12:88, and 15:85, respecti
