100368-73-8Relevant academic research and scientific papers
Copper-catalyzed one-pot oxidative amidation of alcohol to amide via C-H activation
Gu, Jiajia,Fang, Zheng,Yang, Yuhang,Yang, Zhao,Wan, Li,Li, Xin,Wei, Ping,Guo, Kai
, p. 89413 - 89416 (2016)
A one-pot oxidative amidation of both aliphatic and aromatic alcohols with N-chloramines, prepared in situ from many types of primary and secondary amines, was developed. This cross-coupling reaction integrates alcohol oxidation and amide bond formation, which are usually accomplished separately, into a single operation. And it was green, simple and convenient, which has a wide substrate scope and makes use of cheap, abundant, and easily available reagents. The practical value of this method is highlighted through the synthesis of a high-profile pharmaceutical agent, acetylprocainamide.
Gold-catalyzed efficient synthesis of azepan-4-ones via a two-step [5+2] annulation
Cui, Li,Ye, Longwu,Zhang, Liming
supporting information; experimental part, p. 3351 - 3353 (2010/07/20)
A surprisingly efficient synthesis of azepan-4-ones via a two-step [5+2] annulation is developed. This reaction involves a key gold catalysis and shows generally high regioselectivities and good to excellent diastereoselectivities.
Catalytic acylation of amines with aldehydes or aldoximes
Allen, C. Liana,Davulcu, Simge,Williams, Jonathan M. J.
supporting information; experimental part, p. 5096 - 5099 (2011/02/21)
The simple nickel salt NiCl2?6H2O catalyzes the coupling of aldoximes with amines to give secondary or tertiary amide products. The aldoxime can be prepared in situ from the corresponding aldehyde. The use of 18O-labeled oximes has allowed insight into the mechanism of this reaction.
Direct and waste-free amidations and cycloadditions by organocatalytic activation of carboxylic acids at room temperature
Al-Zoubi, Raed M.,Marion, Olivier,Hall, Dennis G.
supporting information; experimental part, p. 2876 - 2879 (2009/02/06)
(Chemical Equation Presented) Taming carboxylic acids: ortho-Iodo- and ortho-bromophenylboronic acids are exceptional organocatalysts in atom-economical amidations between free carboxylic acids and amines, including functionalized ones, and can also provide LUMO-lowering activation in [4 + 2] cycloadditions of α,β-unsaturated carboxylic acids.
