RSC Advances p. 89413 - 89416 (2016)
Update date:2022-08-04
Topics:
Gu, Jiajia
Fang, Zheng
Yang, Yuhang
Yang, Zhao
Wan, Li
Li, Xin
Wei, Ping
Guo, Kai
A one-pot oxidative amidation of both aliphatic and aromatic alcohols with N-chloramines, prepared in situ from many types of primary and secondary amines, was developed. This cross-coupling reaction integrates alcohol oxidation and amide bond formation, which are usually accomplished separately, into a single operation. And it was green, simple and convenient, which has a wide substrate scope and makes use of cheap, abundant, and easily available reagents. The practical value of this method is highlighted through the synthesis of a high-profile pharmaceutical agent, acetylprocainamide.
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Doi:10.3987/COM-04-10216
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